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Completed

NCT Number: NCT01892150

Histologic Response to UVA and UVB Exposure During the Use of Sunscreen

Anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

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Key information

Conditions

Solar Elastosis

Age range

35 year–65 year

Sex eligibility

Female

Study type

Interventional

Phase

Not applicable

Primary location

Department of Dermatology, Faculty of Medicine Siriraj Hospital, Mahidol University

Bangkok, 10700, Thailand

About this study

Premature aging can be prevented by using sunscreen. Currently, anti-inflammatory and anti-oxidant agents have become the important ingredients in sunscreen. However, there is no histologic study about the effects of anti-inflammatory and anti-oxidative properties of sunscreen to prevent premature aging from UVA and UVB.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • subjects aged 35-65 years who were scheduled for abdominoplasty
  • the excised area should be larger than 18x10 cm2
  • no skin diseases or lesions on the excised area
  • no topical treatment on excised area more than 1 month prior to this study

Exclusion criteria

  • pregnancy
  • lactation
  • have tattoo or striae distensae on abdomen

Treatment and study plan

Sunscreen

Other

Apply sunscreen before and after UVA and UVB irradiation

Primary outcomes

  1. H&E Staining

    Time frame: 2 Months

    Review difference in H&E staining in tissue biopsy before and after UVA / UVB irradiation

Secondary outcomes

  1. Tyrosinase Staining

    Time frame: 2 Months

    Review difference in Tyrosinase staining in tissue biopsy before and after UVA / UVB irradiation to evaluate the effects of pigment darkening after UV exposure

Other outcomes

  1. 8-OH-dG Staining

    Time frame: 2 Months

    Review difference in 8-OH-dG staining in tissue biopsy before and after UVA / UVB irradiation to evaluate the quantity of free radical species after UV exposure

  2. MMP1 Staining

    Time frame: 2 Months

    Review difference in MMP1 staining in tissue biopsy before and after UVA / UVB irradiation to evaluate the collagen and ground substances destruction after UV exposure

Sponsors and collaborators

Lead sponsor

Mahidol University

Other

Registry information

Official study title

Histologic Response to UVA and UVB Exposure During the Use of Sunscreen With Anti-inflammatory and Anti-oxidant Properties - A Pilot Study

Important dates

Study start
2013
Primary completion
2013
Study completion
2013
First posted
Jul 4, 2013
Registry last updated
Mar 31, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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