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Completed

NCT Number: NCT03110042

HILO-HF Registry: High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure

The HILO-HF Registry is a single centre registry that will be performed to provide information on the usual baseline oxygen saturation (SpO2) in patients presenting to ED with a primary ED diagnosis of AHF

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Key information

Conditions

Acute Heart Failure

Age range

40 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

University of Alberta Hospital / Mazankowski Alberta Heart Institute

Edmonton, Alberta, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients >40 years of age presenting to the ED with AHF
  • With or without tested BNP
  • With or without admission to hospital for treatment of HF\\
  • Patients must be recruited within the first 24 hours of presenting to the ED.

Exclusion criteria

  • Patients on home oxygen
  • Patients with known prior hypercapnic failure (PaCO2>50 mmHg)
  • Asthma
  • Primary pulmonary hypertension
  • Patients requiring urgent positive pressure ventilation or intubation or on >10 L/min oxygen

Treatment and study plan

Primary outcomes

  1. Change in blood oxygen saturation levels from baseline to 72 hours

    Time frame: 72 hours

Secondary outcomes

  1. Dyspnea on visual analogue scale (VAS) to 72 hours

    Time frame: 72 hours

  2. Change in global symptoms using Patient Global Assessment (PGA) measure to 72 hours

    Time frame: 72 hours

  3. Change in Peak Expiratory Flow

    Time frame: 72 hours

  4. Rate of patients with Worsening Heart Failure

    Time frame: 7 days

  5. 30-day composite clinical event (all-cause mortality, HF readmission, days alive and out of hospital)

    Time frame: 30days

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Registry information

Official study title

High Versus Low SpO2 Oxygen Therapy in Patients With Acute Heart Failure

Important dates

Study start
2016
Primary completion
2019
Study completion
2019
First posted
Apr 12, 2017
Registry last updated
Apr 26, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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