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NCT Number: NCT05838950

HIIT Effects on Cardiometabolic Health

The primary aim of this randomized clinical trial is to compare the effects of three different HIIT protocols and a control group on cardiometabolic health in young adults with obesity. Participants will be randomly assigned to one of the following three groups, with each having varying work-to-rest ratios: 1) HIIT-A, 2) HIIT-B, 3) HIIT-C, and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of a running based HIIT program over a 2-week training period. Pre-clinical markers of cardiovascular disease, blood lipids and fasting glucose will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the training cessation (i.e., measure for detraining effect). All measurements will be performed three days before the training program and three days after the intervention to avoid the effect of the last training session. Afterwards, the detraining test will be measured 2 weeks post intervention.

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Key information

Conditions

Obesity Body Weight Cardiovascular Diseases High-Intensity Interval Training Metabolic Disease Metabolic Diseases Nutrition Disorders Nutritional and Metabolic Diseases Overnutrition Overweight Pathological Conditions, Signs and Symptoms Signs and Symptoms

Age range

18 year–25 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Women's Building

Syracuse, New York, 13244, United States

Location status: Recruiting

Location contact

Departments of Exercise Science

CONTACT

315-443-2115

About this study

Introduction: High-intensity interval training (HIIT) compared with other traditional exercise regimens has shown to be effective in improving cardiometabolic health (as measured by lipids, blood pressure [BP], insulin sensitivity, pulse wave velocity) in overweight and obese adults. By knowing which HIIT protocol is more efficacious in improving markers of cardiometabolic disease, exercise physiologists, researchers and clinicians can properly prescribe exercise medicine to obese young adults and possibly prevent disease progression. Therefore, the primary aim of the present research is to compare the effects of 3 different HIIT protocols compared with a control group on cardiometabolic health improvement in young adults with obesity.

Participants: Participants will be randomly assigned to one of the following three groups : 1) HIIT-A (5:25 s; 1:5 ratio), 2) HIIT-B (10:50 s; 1:5 ratio), 3) HIIT-C (20:100 s; 1:5 ratio), and 4) control group. HIIT-A, HIIT-B, and HIIT-C groups will participate in six sessions of running-based HIIT programs over a 2-week training period. The variables will be measured at the following three time points: baseline, post-intervention, and 2 weeks after the TC (i.e., measure for detraining effect).

High-Intensity Interval Training (six sessions over 2 weeks): Heart rate will be recorded - while performing a sprint running based on the wood court. The HIIT intensity will be set at 90% of the fastest baseline with 40 repetitions of 5-seconds work time, 20 repetitions of 10-seconds work time, or 10 repetitions of 20-seconds work time. All participants will perform one bout of sprint running for 5-, 10-, or 20- seconds followed by 25-second, 50-second, or 100-seconds resting. The supervisor will verbally encourage the running to inspire the sprint at "all-out" intensity. Note that a total of 200-seconds workout time is required per session.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Young adults with obesity (Age 18 to 25 years old, BMI ≥ 30 kg/m2).

Exclusion criteria

  • Syndromic obesity; 1) Any clinical symptoms including cognitive delay, 2) abnormalities in body structure(s), 3) organ-specific abnormalities (kidney, liver failure, excessive eating, and/or other signs of hypothalamic dysfunction such as fatigue, weakness and/or lack of interest in activities.
  • Taking weight loss medication(s)
  • Currently enrolled (or within previous 6 months) in a weight loss program;
  • An underlying disease/medications (steroids, second generation psychotropic agents, hormonal contraception, statins, antihypertensive and antidiabetic medications) that could influence carbohydrate or lipid metabolism.
  • Presence of cardiac pacemaker.
  • Current or anticipated participation in another research that would interfere with any of the outcomes.
  • Current or anticipated pregnancy.

Treatment and study plan

high-intensity interval training intervention

Other

Intervention groups include 3 arms with 3 different HIIT protocols to identify optimal exercise regimen for improving cardiometabolic health in young adults with obesity.

Primary outcomes

  1. Height

    Time frame: Baseline

    Height (cm)

  2. Weight

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Weight (kg); Change from Baseline weight at 2 week and 4 week

  3. Body mass index

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Body mass index (kg/m2); Change from Baseline BMI at 2 week and 4 week

  4. Percentage body fat

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Percentage body fat (kg); Change from Baseline percentage body fat at 2 week and 4 week

  5. Fat mass

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Fat mass (kg); Change from Baseline fat mass at 2 week and 4 week

  6. Lean mass

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Lean mass (kg); Change from Baseline lean mass at 2 week and 4 week

  7. Systolic blood pressure

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Systolic blood pressure (SBP, mmHg); Change from Baseline SBP at 2 week and 4 week

  8. Diastolic blood pressure

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Diastolic blood pressure (DBP, mmHg); Change from Baseline DBP at 2 week and 4 week

  9. Mean arterial pressure

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Mean blood pressure (MAP, mmHg); Change from Baseline MAP at 2 week and 4 week

  10. Flow-mediated dilation

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Flow-mediated dilation (FMD, mm); Change from Baseline FMD at 2 week and 4 week

  11. Carotid-femoral Pulse Wave Velocity (cPWV)

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    cPWV (m/s); Change from Baseline cPWV at 2 week and 4 week

  12. Total cholesterol

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Total cholesterol (mg/dl); Change from Baseline TC at 2 week and 4 week

  13. LDL-C

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    LDL-C (mg/dl); Change from Baseline LDL-C at 2 week and 4 week

  14. HDL-C

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    HDL-C (mg/dl); Change from Baseline HDL-C at 2 week and 4 week

  15. Triglycerides

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Triglycerides (TG, mg/dl); Change from Baseline TG at 2 week and 4 week

  16. Glucose

    Time frame: Baseline, post test (2 weeks of intervention), training cessation (2 weeks of detraining)

    Glucose (mg/dl); Change from Baseline glucose at 2 week and 4 week

Study contacts

Contact information is provided by the study sponsor or research team.

Myong Won Seo, Ph.D

CONTACT

[email protected]

3154012723

Wonhee Cho, MS

CONTACT

[email protected]

6267270270

Sponsors and collaborators

Lead sponsor

Syracuse University

Other

Registry information

Official study title

Detraining Effect of Short-term HIIT on Cardiometabolic Risk in Young Adults With Obesity

Important dates

Study start
2023
Primary completion
2025
Study completion
2025
First posted
May 3, 2023
Registry last updated
Jul 23, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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