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Completed

NCT Number: NCT03342846

High Versus Low Frequency rTMS on Motor Dysfunction in PD

The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study.

The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.

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Key information

Conditions

Parkinson Disease Basal Ganglia Diseases Brain Diseases Central Nervous System Diseases Movement Disorders Nervous System Diseases Neurodegenerative Diseases Parkinsonian Disorders Synucleinopathies

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Eman Khedr

Asyut, 11517, Egypt

About this study

The aim of the study is to compare high versus low frequency rTMS on motor dysfunction in PD. Forty patients with PD participated in the study.

The patients were randomly assigned into two groups; the first group received 1Hz and the 2nd one received 20 Hz rTMS daily for 10 days 5 sessions every week and 2 days off per week. The doctors who assess the patients clinically is blind for the frequency of rTMS, also patients don't know which type of stimulation they received. The patients were followed up before and after the 10 sessions and one month later.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All PD patients who were diagnosed according to UK bank criteria for PD.

Exclusion criteria

  • History of repeated head injury.
  • History of repeated cerebrovascular strokes
  • History of defined encephalitis
  • Oculogyric crisis, supra nuclear gaze palsy.
  • Family history of more than one relative
  • severe dementia, MMSE < 23, severe depression
  • Cerebellar signs
  • Babiniski sign
  • Hydrocephalus or intracranial lesion on neuroimaging
  • Patients with intracranial on neuroimaging
  • Patients with intracranial metallic device or pacemaker
  • Patients who were unable to give informed consent because of severe anesthesia, or cognitive deficit

Treatment and study plan

rTMS

Device

the first group received 20 Hz and the 2nd group received 1 Hz rTMS daily for 10 days 5 sessions every week on M1.

Primary outcomes

  1. change in motor disability

    Time frame: one month

    Measure the change in motor disability by using UPDRS and self assessment scale

Secondary outcomes

  1. Changes in Cortical excitability

    Time frame: Two weeks

    Measure the changes in cortical excitability using magnetic stimulation appratus

Sponsors and collaborators

Lead sponsor

Assiut University

Other

Registry information

Official study title

The Effect of High Versus Low Frequency Repetitive Transcranial Magnetic Stimulation on Motor Dysfunction in Parkinson's Disease; Which is More Beneficial?

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Nov 17, 2017
Registry last updated
Sep 16, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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