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Completed

NCT Number: NCT07076745

High-Sensitive CRP and Carotid Stiffness Between Patients With and Without Coronary Slow Flow

This study aims to compare the levels of high-sensitivity C-reactive protein (hs-CRP) and carotid artery stiffness between patients with coronary slow flow phenomenon (CSFP) and those with normal coronary flow.

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Key information

Conditions

High-sensitivity C-reactive Protein Carotid Stiffness Coronary Slow Flow

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Sohag University

Sohag, 82511, Egypt

About this study

The coronary slow flow phenomenon (CSFP) is characterized by delayed opacification of the coronary arteries during angiography in the absence of significant epicardial coronary artery disease.

Hypothesis: High-sensitivity C-reactive protein (hs-CRP) is a well-established biomarker of systemic inflammation and has been associated with various cardiovascular conditions. Elevated hs-CRP levels have been observed in patients with CSFP, suggesting an inflammatory component in its pathogenesis. This marker not only predicts future cardiovascular events but may also reflect ongoing vascular inflammation in patients with angiographically normal coronary arteries.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 years old.
  • Both sexes.
  • Patients undergo coronary angiography for evaluation of chest pain or suspected ischemia.

Exclusion criteria

  • Pregnant or breastfeeding women.
  • History of cardiovascular events such as myocardial infarction or stroke.
  • Diagnosed autoimmune disorders, chronic hepatic or renal diseases.
  • Current or recent infections.
  • History of malignancy.
  • Patients taking medications known to affect inflammatory markers (e.g., corticosteroids or immunosuppressants).

Treatment and study plan

High-sensitivity C-reactive protein

Diagnostic Test

High-sensitivity C-reactive protein will be done.

Stiffness Measurement

Other

Measurements will include carotid intima-media thickness (CIMT), systolic (Ds) and diastolic (Dd) diameters, and calculation of stiffness indices:

  • β-stiffness index.
  • Peterson's elastic modulus (Ep).
  • Distensibility coefficient (DC).
  • Compliance coefficient (CC).
  • Strain.

Primary outcomes

  1. High Sensitive C-reactive protein

    Time frame: 24 hours post-angiography

    High Sensitive C-reactive protein will be measured.

Secondary outcomes

  1. Stiffness indices

    Time frame: 24 hours post-angiography

    Stiffness indices will be measured.

Sponsors and collaborators

Lead sponsor

Sohag University

Other

Registry information

Official study title

Comparative Assessment of High Sensitive CRP and Carotid Stiffness Between Patients With and Without Coronary Slow Flow

Important dates

Study start
2025
Primary completion
2025
Study completion
2025
First posted
Jul 22, 2025
Registry last updated
Jul 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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