High Plasma Level of Long Pentraxin 3 is Associated With Insulin Resistance in Women With Polycystic Ovary Syndrome (PCOS)

In the present study, serum pentraxin 3 level and its relationship with insulin resistance were determined in patients with Polycystic Ovary Syndrome (PCOS. It was found that PTX3 level is increased in patients with PCOS and it is positively correlated with HOMA-IR.

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Key information

Conditions

PCOS Adnexal Diseases Cysts Endocrine System Diseases Female Urogenital Diseases Female Urogenital Diseases and Pregnancy Complications Genital Diseases Genital Diseases, Female Gonadal Disorders Neoplasms Ovarian Cysts Ovarian Diseases Polycystic Ovary Syndrome Urogenital Diseases

Age range

18 year–40 year

Sex eligibility

Female

Study type

Observational

Primary location

Gulhane School of Medicine, Ankara, Turkey (Türkiye)

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Absence of significant abnormalities on physical examination except hirsutism
No lipid lowering, hypoglycemic, antihypertensive or hormone replacement therapy
Normal thyroid function and prolactin level
Absence of history or evidence of metabolic, cardiovascular, respiratory or hepatic disease

Exclusion criteria

Pregnant
Possible ovarian tumors,
Congenital adrenal hyperplasia or
BMI greater than 35 kg/m2

Treatment and study plan

Primary outcomes

Level of of pentraxin3 in cases with Polycystic Ovarian Syndrome

Time frame: 1 year

Mean PTX3 was significantly higher in patients with PCOS. This means that there is increased level of inflamation in patients with PCOS.

Secondary outcomes

Relationship of PTX3 with insuline resistance in patients with PCOS.

Time frame: 1 year

PTX3 was positively correlated with HOMA-IR. This means that inflamation may cause insuline resistance in patients with PCOS.

Sponsors and collaborators

Lead sponsor

Gulhane School of Medicine

Other

Registry information

Official study title

High Plasma Level of Long Pentraxin 3 is Associated With Insulin Resistance in Women With Polycystic Ovary Syndrome

Important dates

Study start: 2010
Study completion: 2011
First posted: Nov 2, 2011
Registry last updated: Nov 2, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed