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OpenTrials
Completed

NCT Number: NCT03568864

High Nucleotide Meal Consumption in Uric Acid and Metabolic Health

The production of protein rich animal products is associated with a large environmental burden, and with ethical considerations. Additionally, the over-consumption of meat might be associated with detrimental effects to health.

Using mycoprotein, a food ingredient derived from the fermentation of a fungus, as a meat substitute could result in environmental benefits, and could have a role in managing obesity, diabetes and improving metabolic health. However, naturally produced mycoprotein has a high nucleotide content and little is known about the impact of nucleotides in uric acid levels and other health markers.

The aim of this study is to investigate the effect of a meal based on nucleotide rich mycoprotein on uric acid concentrations and other markers of health.

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Key information

Conditions

Healthy

Age range

18 year–40 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

St Luke's Campus - University of Exeter

Exeter, Devon, EX1 2LU, United Kingdom

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • BMI between 18 and 30

Exclusion criteria

  • On medication (except contraception)
  • Smokers
  • Diagnosed with any metabolic or cardiovascular conditions
  • BMI < 18 or > 30

Treatment and study plan

Low nucleotide meal

Other

The participants will consume a mixed meal (sandwich) containing a nucleotide depleted mycoprotein product (low in nucleotides)

High nucleotide meal

Other

The participants will consume a mixed meal (sandwich) containing a non nucleotide depleted mycoprotein product (high in nucleotides)

Primary outcomes

  1. Changes in serum uric acid concentrations over a 24 h period

    Time frame: Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 8, 12 and 24 hours after meal

Secondary outcomes

  1. Blood glucose

    Time frame: Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal; 24 hours after meal

  2. Serum insulin

    Time frame: Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal

  3. Branched chained amino-acids

    Time frame: Baseline; 15, 30, 45, 60, 90, 120, 150, 180, 210 and 240 minutes after meal

Sponsors and collaborators

Lead sponsor

University of Exeter

Other

Registry information

Official study title

The Acute Effect of a High Nucleotide Mycoprotein Meal in Uric Acid Concentrations and Other Markers of Health

Acronym: TIDE

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Jun 26, 2018
Registry last updated
Jun 26, 2018

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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