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Completed

NCT Number: NCT03487029

High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes

Aim: To assess whether there are different training effects on glucose concentration and cardiorespiratory parameters of different high-intensity training protocols in patients with type 2 diabetes.

Type 2 diabetes is a highly prevalent disease associated with cardiovascular disease leading to high levels of mortality, morbidity and health expenditure, characterized by impaired glucose control during activities and reduced aerobic exercise capacity .

Exercise training is the most effective way to improve compliance, reduce blood glucose concentration and increase insulin sensitivity. Training increases muscle capacity, oxidative capacity and glucose transport, peripheral insulin sensitivity is improved.

Exercise training with high-intensity interval (resting and exercise period) High Intensity Interval Training (HIIT) is a form of exercise training that has recently been widely used in the management of type 2 diabetes, including short duration high intensity exercise periods and lower severity or passive rest periods. There are different HIIT exercise training programs according to physiological responses in the literature. However, long-term and short-term HIIT training training programs were not compared in terms of their effect on glucose concentration and cardiorespiratory fitness. The aim of this study was to compare the effects of different HIIT exercise training programs so that exercise programs for patients with type 2 diabetes could be planned more effectively.

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Key information

Age range

18 year–64 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hacettepe University

Ankara, State, 06100, Turkey (Türkiye)

About this study

This study will be participated patients with Type 2 diabetes. Patients' laboratory values, pulmonary function test, respiratory muscle strength, exercise capacity, physical activity level, quality of life will be evaluated.

Pulmonary function test will be assesed with spirometer, respiratory muscle strength will be evaluated with mouth pressure. Exercise capacity will be evaluated using six minute walking test, incremental shuttle walk test, cycle ergometer. Muscle oxigeneration will be asssed with wearable lactate threshold predicting device. Physical activity level will be evaluated trial accelerometer.

Then, patients will be randomly divided two high intensity interval exercise training groups.

First group: short duration high intensity exercise training (Exercise load phase : 30sn %100 Patients performance, rest phase: 120sn %25 patients performance) Second group: Long duration high intensity interval exercise training (Exercise load phase : 4 dk %100 Patients performance, rest phase: 120sn %25 patients performance) All patients will participate three times a week during eight weeks. The muscle oxigeneration, blood glucose consantration, blood pressure, heart rate will be recorded before and after each exercise session. After 8 week, all test will be done again.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • diagnosis of type 2 diabetes
  • aged 18-64 years
  • patients can walk and cooperative
  • body mass index is less than 40 kg / m2

Exclusion criteria

Individuals have known lung disease,have undergone any cardiac event or surgery within the past six months, have uncontrolled hypertension, and have diabetic complications such as nephropathy, retinopathy and severe neuropathy.

Treatment and study plan

Short duration

Other

exercise Short duration high intensity training

Other names: training

Long duration

Other

exercise Long duration high intensity training

Other names: training

Primary outcomes

  1. muscle oxigeneration

    Time frame: Change from baseline muscle oxigeneration at 8 weeks

    It is evaluate with wearable lactate threshold device on gastrocinemius

Secondary outcomes

  1. The blood glucose consentration

    Time frame: before and after 8 weeks

    It is evaluate with sample from blood

  2. Functional Exercise capacity

    Time frame: before and after 8 weeks

    İt is evaluated with six minute walk test

  3. Maximal exercise capacity

    Time frame: before and after 8 weeks

    İt is evaluated using with incremental shuttle test

  4. Symptom limited maximal exercise capacity

    Time frame: before and after 8 weeks

    İt is evaluated with cycle ergometer test

  5. Lipit profile-High density lipoprotein cholesterol

    Time frame: before and after 8 weeks

    High density lipoprotein cholesterol wiil be assesed

  6. Lipit profile- low density lipoprotein cholesterol

    Time frame: before and after 8 weeks

    low density lipoprotein cholesterol wiil be assesed

  7. Lipit profile- trigliseride

    Time frame: before and after 8 weeks

    trigliseride wiil be assesed

  8. pulmonary parameter-Forced vital capacity

    Time frame: before and after 8 weeks

    Forced vital capacity will be evaluated

  9. pulmonary parameter-Forced vital capacity in the first second

    Time frame: before and after 8 weeks

    Forced vital capacity in the first second will be evaluated

  10. pulmonary parameter-Mid expiratory flow rate

    Time frame: before and after 8 weeks

    Mid expiratory flow rate will be evaluated

  11. pulmonary parameter-Peak expiratory flow

    Time frame: before and after 8 weeks

    Peak expiratory flow will be evaluated

  12. Respiratory muscle strength

    Time frame: before and after 8 weeks

    It is evaluated with mouth pressure

  13. Physical activity level

    Time frame: before and after 8 weeks

    ıt is assessed using accelerometer

Sponsors and collaborators

Lead sponsor

Hacettepe University

Other

Registry information

Official study title

The Effects of Different High-intensity Interval Training Training Protocols on Cardiorespiratory Parameters in Patients With Type 2 Diabetes

Important dates

Study start
2018
Primary completion
2018
Study completion
2020
First posted
Apr 3, 2018
Registry last updated
Apr 9, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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