NCT Number: NCT02444377
High-intensity Interval Training in Overweight/Obese
Purpose: The purpose of this study would be to evaluate the effects of interval training on cardiovascular health, lipid profile and body composition in overweight and obese men and women.
A secondary purpose will be to compare lab based measurements of body composition [4-compartment model (4C)) with portable equipment [bioelectrical impedance spectroscopy (BIS) and ultrasound (US)]
Participants: Seventy-six men and women (age 18-55 yrs; BMI 25-45 kg/m2) will be randomly assigned to a high-intensity short interval group (SIT), high-intensity long interval group (HIT) or a control group (CON). Procedures (methods): Participants will be assessed for peak oxygen utilization (VO2peak), blood lipids, glucose and insulin levels. Body composition will also be measured using a 4C model, as measured from dual energy x-ray absorptiometry (DEXA), air displacement plethysmography (BodPod), and BIS, in comparison to US values. Participants assigned to either training group will undergo 3 weeks of interval training, 3 days per week. SIT will complete 10 bouts of a series of 1 min cycling with 1 min rest periods at 90% of the power output obtained during VO2peak;in comparison HIT will complete 5 bouts of the same protocol: 2 min bouts with 1 min recovery at varying intensities of VO2peak (80-100% power output).
Looking for future studies?
Notify MeKey information
Conditions
Age range
18 year–55 year
Sex eligibility
All sexes
Study type
Interventional
Phase
Not applicable
Who can participate
Healthy volunteers accepted: Yes
Only the study team can determine whether someone qualifies for participation.
Inclusion criteria
- written and dated informed consent to participate in the study.
- willing and able to comply with the protocol.
- good health as determined by a health and exercise status questionnaire
- normal electrocardiogram (ECG), and physical.
- body mass index of 25-45 kg/m 2.
- has been cleared for participation by a physician (either study or personal).
Exclusion criteria
- participating in another clinical trial or have received an investigational product within thirty days prior to enrollment.
- has lost ten or more pounds during the previous three months and maintained the weight loss.
- significant history or current presence of untreated high blood pressure (BP) [systolic BP> 140 mmHg and/or diastolic BP> 90 mmHg], thyroid disease, tachyarrhythmia, heart disease, kidney disease, or liver disease. Subject currently suffers from/or has a known history of (or is currently being treated for) clinical depression or an eating disorder(s).
- has any medical condition or uses any medication, nutritional product, dietary supplement or program, which in the opinion of the investigator, might interfere with the conduct of the study or place the subject at risk.
- are identified as moderate to high risk individuals by the American College of Sports Medicine will be excluded from the study.
Treatment and study plan
Primary outcomes
-
Cardiorespiratory Fitness (VO2peak)
Time frame: 3 weeks
Secondary outcomes
-
Body Composition
Time frame: 3 weeks
-
Blood Lipids
Time frame: 3 weeks
Sponsors and collaborators
Lead sponsor
University of North Carolina, Chapel Hill
Other
Registry information
Official study title
Impact of Varying High-intensity Interval Protocols on Cardiometabolic Risk Factors in Overweight/Obese
Important dates
- Study start
- 2012
- Primary completion
- 2014
- Study completion
- 2014
- First posted
- May 14, 2015
- Registry last updated
- Nov 30, 2016
OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.
View the official ClinicalTrials.gov record (opens in a new tab)This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.
Related clinical trials
Published trials that share one or more normalized conditions with this study.
Tuna Based Nuggets and Ischemic Cardiomyopathy
NCT07462858
Body Weight, Ischemic Cardiomyopathy
Lahore, Pakistan
View Trial DetailsMetabolomics and Bariatric Surgery in Patients With Metabolically Unhealthy Obesity
NCT06297928
Bariatric Surgery Candidate, Body Weight
Barcelona, Spain
View Trial DetailsOxidative Stress, Inflammation, and Lipoprotein in Metabolic Syndrome
NCT03553381
Body Weight, Glucose Metabolism Disorders
Milan, Italy
View Trial DetailsEffect of Diet and Physical Activity on Adipokines
NCT03435978
Body Weight, Glucose Metabolism Disorders
View Trial Details