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NCT Number: NCT07138638

High-Frequency QRS for Predicting Microvascular Dysfunction and Adverse Events After PCI in Acute Myocardial Infarction

This observational study aimed to investigate the prognostic value of high-frequency QRS (HF-QRS) in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI), as well as its potential role in diagnosing microvascular dysfunction. The main question it aims to answer is:

1. Whether HF-QRS could serve as an effective tool for early identification of high-risk AMI patients and prognosis prediction; 2. Whether HF-QRS provides auxiliary diagnostic value for post-AMI microvascular dysfunction.

Participants underwent HF-QRS assessment and were prospectively followed for 1 year to record the incidence of major adverse cardiovascular events (MACE).

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Key information

Conditions

AMI

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

The Affiliated Hospital of Xuzhou Medical University

Xuzhou, Jiangsu, 221000, China

Location contact

Yuan Lu, Ph.D

CONTACT

[email protected]

13952110901

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Aged 18 to 75 years (inclusive)

Diagnosed with acute myocardial infarction (AMI, including STEMI and NSTEMI) and underwent successful emergency PCI

Voluntarily participated and provided written informed consent

Exclusion criteria

  • History of prior myocardial infarction or chronic heart failure

QRS duration >120 ms (including paced rhythm, WPW syndrome, bundle branch block, or left ventricular hypertrophy with repolarization abnormalities)

Structural heart disease (congenital heart disease, cardiomyopathy, aortic dissection, etc.)

Persistent atrial fibrillation or malignant arrhythmias

History of cerebral hemorrhage or ischemic stroke within 1 month

Prolonged cardiopulmonary resuscitation or requiring advanced life support (IABP/ECMO, etc.)

Scheduled for imminent surgery with anticipated inability to complete HF-QRS assessment

Other life-threatening conditions including: Severe hepatic or renal dysfunction;Uncontrolled systemic diseases;Hematologic disorders;Active infections;Malignancy with life expectancy <1 year Other investigator-determined exclusionary conditions:Pregnancy;Concurrent participation in other clinical trials

Refusal to participate in the clinical study

Treatment and study plan

High-Frequency QRS

Device

All enrolled patients underwent HF-QRS assessment, with subsequent recording of MACE to evaluate the predictive value of HF-QRS parameters for clinical outcomes

Primary outcomes

  1. To evaluate the predictive value of high-frequency QRS (HF-QRS) parameters for major adverse cardiovascular events (MACE) within 1 year after PCI in AMI patients and to construct a prognostic risk prediction model.

    Time frame: 12 months

Secondary outcomes

  1. To evaluate the adjunctive diagnostic value of high-frequency QRS parameters for microvascular dysfunction in ACS patients following percutaneous coronary intervention

    Time frame: 12 months

Study contacts

Contact information is provided by the study sponsor or research team.

Yuan Lu, Ph.D

CONTACT

[email protected]

13952110901

Sponsors and collaborators

Lead sponsor

The Affiliated Hospital of Xuzhou Medical University

Other

Registry information

Official study title

High-Frequency QRS for Predicting Microvascular Dysfunction and Adverse Events After PCI in Acute Myocardial Infarction: A Prospective, Multicenter Cohort Study

Important dates

Study start
2025
Primary completion
2027
Study completion
2027
First posted
Aug 24, 2025
Registry last updated
Aug 24, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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