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Completed

NCT Number: NCT06537388

High Frequency Jet Ventilation Versus Conventional Positive Pressure Ventilation for EBUS

Endobronchial ultrasound (EBUS) is frequently used in pneumology for diagnostic procedures like mediastinal biopsies. This procedure is usually done under general anesthesia. Different methods of ventilation are used according to center and physician preferences. In this retrospective study, complications of 2 types of ventilation will be analyzed:

* High frequency jet ventilation (HFJV) * Conventional intermittent positive pressure ventilation (IPPV) Descriptive statistics will be used to present the data. Both ventilation techniques will be compared after propensity score matching. For HFJV patients from 2019 will be analyzed and for IPPV patients from 2023, as the team changed its practice over time.

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Key information

Conditions

Intermittent Positive-pressure Ventilation High-Frequency Jet Ventilation Ultrasonography, Interventional

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Hôpital Universitaire de Bruxelles - Hôpital erasme

Brussels, 1070, Belgium

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • All patients who underwent EBUS at Erasme University Hospital using either HFJV or IPPV between january 1st 2019 and december 31st 2019 or january 1st 2023 and december 31st 2023.

Exclusion criteria

  • Incomplete medical chart
  • Patients who expressed an opposition to the use of their medical data
  • Age < 18 years

Treatment and study plan

Ventilation type

Procedure

Type of ventilation used during the EBUS procedure, either HFJV or IPPV

Primary outcomes

  1. Hypoxia

    Time frame: 24 hours

    defined as an SpO2 < 90% for more than 1 min

  2. Severe hypoxia

    Time frame: 24 hours

    defined as an SpO2 (oxygen saturation by pulse oximetry) < 85% for more than 1 min

  3. Hemodynamic instability

    Time frame: 24 hours

    defined as a systolic arterial blood pressure < 90/60 mm Hg

  4. Cardiac arrythmia

    Time frame: 24 hours

    Any cardiac rhythm other than sinus rhythm

  5. Laryngospasm

    Time frame: 24 hours

    Any occurence of laryngospasm

  6. ICU admission

    Time frame: 24 hours

    Necessity for admission to the intensive care unit (ICU)

Sponsors and collaborators

Lead sponsor

Erasme University Hospital

Other

Registry information

Official study title

Comparison of High Frequency Jet Ventilation and Conventional Positive Pressure Ventilation for Endobronchial Ultrasound Examinations

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Aug 5, 2024
Registry last updated
May 21, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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