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OpenTrials
Completed

NCT Number: NCT05527431

High Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypoxic Respiratory Failure Following Blunt Chest Trauma

to compare high flow nasal cannula against noninvasive ventilation in patients with non-sever blunt chest trauma in improvement of oxygenation, need for intubation and mechanical ventilation within 28 days

Completed

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Key information

Conditions

Blunt Injury of Thorax

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Ain Shams University hospitals

Cairo, 11591, Egypt

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥18 y,
  • Willing and able to provide written informed consent prior to performing study procedures,
  • currently hospitalized and requiring medical care for non-sever blunt chest trauma (abbreviated injury severity scale ≤ 2) SpO2 90% or less while breathing 10 L/min.

Exclusion criteria

  • Contraindications of noninvasive ventilation (face trauma or surgery, airway obstruction, upper gastrointestinal tract bleeding, disturbed level of consciousness), -smoker
  • intubation for any cause other than respiratory cause

Treatment and study plan

High Flow Nasal Cannula

Device

high flow nasal cannula

Noninvasive Ventilation

Device

noninvasive ventilation

Primary outcomes

  1. PaO2/FiO2 ratio

    Time frame: 3 successive days

    mean value of three successive PaO2/FiO2 ratio in mmHg between both groups

Secondary outcomes

  1. Discomfort score

    Time frame: 3 successive days

    Discomfort related to oxygen delivery devices will be evaluated using a 10- point numeric scale which low number is low discomfort.

Sponsors and collaborators

Lead sponsor

Ain Shams University

Other

Registry information

Official study title

High Flow Nasal Cannula vs Noninvasive Ventilation in Patients With Hypoxic Respiratory Failure Following Blunt Chest Trauma, a Randomized Clinical Trial

Important dates

Study start
2022
Primary completion
2024
Study completion
2024
First posted
Sep 2, 2022
Registry last updated
Jun 4, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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