High-field MR Imaging in Migraine, Visual Snow and Epilepsy

Inclusion criteria

Patients:

• Patient must be able to read and sign the informed consent form
• Stable prophylactic medication for 2 months prior to MRI
• At leat one of the two criteria applies:
• Patients diagnosed with migraine (with or without aura, episodic or chronic). Diagnosis is ensured by clinical interview (at least 8 weeks prior to MRI). Also, patients complete a migraine questionnaire (HARDSHIP) (at least 8 weeks before MRI). Migraine frequency ≥ 2 migraine attacks/month.
• Patients with drug resistent epilepsy accroding to ILAE crtieria
• Patients with diagnoses of Visual snow syndrome

Healthy participants;

• No migraine (validated by questionnaire) or epilepsy
• Participants must be able to read and sign the informed consent form

Exclusion criteria

• Treatment of migraine disease with Botox within < 4 months before baseline and during the study period
• Pregnant or breastfeeding women
• Intention during the course of the trial to become pregnant
• Women with bilateral ovariectomy, with or without hysterectomy, and postmenopausal women (>2 years of age) are not considered childbearing.
• Other clinically significant comorbidities (e.g., renal insufficiency, hepatic dysfunction, cardiovascular disease, etc.),
• Known or suspected noncompliance with the protocol, drug or alcohol abuse,
• Patient's inability to follow trial procedures, e.g., due to language problems, mental illness, dementia, etc.,
• Prior participation in the clinical trial
• Enrolment of the investigator, his/ her family members, employees and other dependent persons of the test personnel
• Metallic objects in the body (e.g., splinters, MR incompatible implants).
• Pacemaker
• Claustrophobia
• Obesity (body mass index > 35 kg/m2)