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NCT Number: NCT02053701

High-field Brain Magnetic Resonance Spectroscopy

Magnetic resonance spectroscopy (MRS) allows non-invasive measurement of the concentration of up to 18 metabolites in the brain ("neurochemical profile").

The objective of this proposal is to develop new methods for high-field brain MRS (3 to 7 Tesla).

Our main hypothesis is that higher magnetic fields lead to improved spatial and temporal resolution and improved quantification precision.

Aims

1. To obtain improved "neurochemical profiles" in the brain using single voxel proton MRS at very high field (3 Tesla to 7 Tesla). 2. To develop new methods for proton magnetic resonance spectroscopic imaging (MRSI) to obtain metabolic maps at very high field (3 Tesla to 7 Tesla).

Since this project is focused on technical development, only healthy volunteers will be recruited (no patients).

Active, Not Recruiting

This study is active but is not currently recruiting participants.

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Key information

Conditions

Healthy

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Center for Magnetic Resonance Research

Minneapolis, Minnesota, 55455, United States

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • over 18 years old

Exclusion criteria

  • no metallic implant or other MRI-incompatible device

Treatment and study plan

Primary outcomes

  1. Precision of quantification of brain metabolites concentrations

    Time frame: One time only

    This protocol is devoted exclusively to technical development and testing of MRS methods on our MR scanners. As such, there is no well-defined outcome measure or time frame. It is a continuous effort. We recruit subjects on an ongoing basis to test, optimize, and assess the performance of newly developed techniques.

Sponsors and collaborators

Lead sponsor

University of Minnesota

Other

Collaborators

  • National Institute for Biomedical Imaging and Bioengineering (NIBIB)

Registry information

Official study title

Technical Developments for High-field Brain Magnetic Resonance Spectroscopy

Important dates

Study start
2010
Primary completion
2030
Study completion
2030
First posted
Feb 4, 2014
Registry last updated
Mar 19, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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