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OpenTrials
Active, Not Recruiting

NCT Number: NCT06924684

High-Dose Rosuvastatin Preloading for Enhanced Outcomes in STEMI Patients Undergoing Primary PCI

To compare the efficacy of high dose rosuvastatin preloading vs placebo before primary PCI in terms of MACE at 30 days

Active, Not Recruiting

This study is active but is not currently recruiting participants.

Key information

Conditions

ST Elevation (STEMI) Myocardial Infarction Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases

Age range

18 year–75 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 2

Primary location

Punjab Institute of Cardiology, Lahore, Pakistan

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age 18-75 years Patients undergoing primary angiography

Exclusion criteria

  • Hemodynamically unstable patients. History or clinical evidence of any co-morbidities. Taking any medications regularly even statins.

Treatment and study plan

Statin monotherapy (rosuvastatin or atorvastatin)

Drug

Tab Rosuvastatin 40mg (weight) at presentation. Tab Rosuvastatin 20mg at night for 30 days.

Other names: Rosuvastatins

Placebo

Drug

Placebo caspule

Primary outcomes

  1. Incidence of MACE

    Time frame: 30 days

  2. In-Hospital mortality

    Time frame: 30 days

Sponsors and collaborators

Lead sponsor

Sheikh Zayed Federal Postgraduate Medical Institute

Other

Collaborators

  • Punjab Institute of Cardology

Registry information

Official study title

Efficacy Of High-Dose Rosuvastatin Preloading Before Primary Percutaneous Coronary Intervention In Patients Suffering From St-Elevation Myocardial Infarction

Acronym: HEROS-PCI

Important dates

Study start
2024
Primary completion
2025
Study completion
2025
First posted
Apr 11, 2025
Registry last updated
Apr 11, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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