High Dose of Vitamin C on Mechanically Ventilated Septic Patients in Intensive Care Unit

This study will be carried out in intensive care unit in Ain Shams University Hospitals , Cairo,Egypt on 40 patients admitted to ICU that are septic patients and mechanically ventilated which will be recruited into the study . After approval from ethical committee, an informed consent will be obtained from relatives of all patients. All data of patients will be confidential with secret codes and private file for each patient. Each patient's relative will receive an explanation for the purpose of the study. The study design will be prospective , randomized clinical trial.

Methodology:

All patients will be subjected to:

• Complete history taking.
• Full clinical examination
• Evaluation and monitoring of(pulse oximetry , ECG, NIBP, temperature)
• CBC , Blood gas (for determination of (PaO2/FiO2), Blood cultures,serum Creatinine and total bilirubin were recorded daily for the first 7 days.
• Severity scores by calculating Acute physiology and chronic health evaluation (APACHE II)score

Inclusion criteria

• Male or Female
• Age from age≥18 years
• Septic patient admitted to ICU and mechanically ventilated diagnosed by sepsis criteria proposed by the American College of Chest Physicians/Society of Critical Care Medicine
• Expected to survive and remain in the ICU for at least 96 hours after study entry

Exclusion criteria

• Age<18 years
• Pregnant females
• Patients with history of aspiration before intubation
• Respiratory distress syndrome
• Ischemic reperfusion injury
• Cancer as the cause of SIRS or sepsis
• Chronic kidney diseases
• Ongoing shock
• Allergy from interventional drug on the study