Skip to main content
OpenTrials
Completed

NCT Number: NCT00154050

High Dose Candesartan Versus Quinapril for Restenosis Prophylaxis After Stent Angioplasty

The study is designed to test the hypothesis that high dose candesartan treatment compared to quinapril is able to reduce intima hyperproliferation and the restenosis rate after stent angioplasty in peripheral occlusive artery disease.

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Arterial Occlusive Diseases Cardiovascular Diseases Vascular Diseases

Age range

18 year–80 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Chemnitz Hospital, Dept. of Internal Medicine I

Chemnitz, 09313, Germany

About this study

Patients are randomly assigned to treatment with either candesartan 32 mg/d or Quinapril 20 mg/d before the angioplasty. Walking distance, intima media thickness and crurobrachial pressure ratios are compared after 6 weeks, 3 months and 6 months. After 6 months an angiographic control is performed.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • male and female
  • peripheral occlusive arterial disease Stad IIb Fontaine classification

Exclusion criteria

  • patients with lesions not available for PTA
  • renal insufficiency
  • patients on calcium-antagonists

Treatment and study plan

candesartan (drug) or quinapril (drug)

Drug

Primary outcomes

  1. Restenosis/reintervention after 6 months

Secondary outcomes

  1. pain-free walking distance

  2. crurobrachial pressure ratios

Sponsors and collaborators

Lead sponsor

Technische Universität Dresden

Other

Registry information

Important dates

Study start
2004
Study completion
2006
First posted
Sep 12, 2005
Registry last updated
Sep 12, 2006

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.