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Completed

NCT Number: NCT01306565

High Dose and Low Dose of Atorvastatin in Patients With Unstable Angina and NSTEMI (Non ST Elevation MI)

The aim of this study is to compare the effect of high dose and low dose of Atorvastatin in reduction level of C-reactive protein (CRP) in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi hospital in Bandar Abbas.

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Key information

Conditions

Cardiovascular Disease Angina Pectoris Angina, Unstable Cardiovascular Diseases Chest Pain Heart Diseases Myocardial Ischemia Neurologic Manifestations Pain Pathological Conditions, Signs and Symptoms Signs and Symptoms Vascular Diseases

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Hormozgan University of Medical Sciences

Bandar Abbas, Hormozgan, 097145-3388, Iran

About this study

This study compare the effect of 80mg atorvastatin followed by two 20mg daily atorvastatin with three 80mg daily atorvastatin in reduction of CRP in patients with unstable angina and NSTEMI (Non ST Elevation MI) attending Shahid Mohammadi hospital in Bandar Abbas in 2009.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with unstable angina with chest discomfort at rest with normal EKG or St depression (at least 0.1mv) in two consecutive leads or new and deep T inversion (at least 0.2mv)

Exclusion criteria

  • Myocardial Infarction with ST elevation
  • Diabetes Mellitus
  • Previous statin use
  • Current infectious disease

Treatment and study plan

Low dose Atorvastatin

Drug

80mg atorvastatin followed by two 20mg daily atorvastatin

Other names: Lipitor

High dose atorvastatin

Drug

80mg daily atorvastatin for 72 hours

Other names: Lipitor

Primary outcomes

  1. CRP reduction

    Time frame: 72 hours

    CRP reduction will be compared between two study groups

Secondary outcomes

  1. Drug side effects

    Time frame: 72 hours

    Headache, Myopathy

Sponsors and collaborators

Lead sponsor

Hormozgan University of Medical Sciences

Other

Registry information

Official study title

Comparison Between Effect of High Dose and Low Dose of Atorvastatin in Reduction Level of CRP in Patients With Unstable Angina and NSTEMI (Non ST Elevation MI)

Important dates

Study start
2009
Primary completion
2010
Study completion
2011
First posted
Mar 2, 2011
Registry last updated
Mar 2, 2011

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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