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Recruiting

NCT Number: NCT05820802

High Dimensional Analysis of Immune Cells in Pediatric Patients

The purpose of this study is to characterize immune cells using single-cell transcriptomic analysis in pediatric patients aged 2 to 18 years undergoing general anesthesia who are expected to receive Rocuronium, a non-depolarizing neuromuscular blocking agent, in the event of an allergic reaction.

Recruiting

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Key information

Conditions

Drug Allergy Chemically-Induced Disorders Drug Hypersensitivity Drug-Related Side Effects and Adverse Reactions Neuromuscular Blockade

Age range

2 year–18 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Seoul National University Hospital

Seoul, South Korea

Location status: Recruiting

Location contact

Young-Eun Jang, MD, PhD

CONTACT

[email protected]

82-2-2072-3650

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Pediatric patients between the ages of 2 and 18 undergoing general anesthesia and surgery using the neuromuscular blocker, rocuronium.

Exclusion criteria

  • Patients who have received immunomodulators, immunosuppressants, etc.
  • Patients with autoimmune diseases (rheumatoid arthritis, lupus, Behcet's disease, etc.)
  • Patients who regularly take, or have taken within 4 weeks, medications that may affect the immune system (oral steroids, anti-inflammatories, etc.)
  • Other cases where the Principal Investigator determines that it is difficult to conduct the study.

Treatment and study plan

Primary outcomes

  1. Transcriptomic profile analysis of the T lymphocytes by RNA sequencing

    Time frame: until end of surgery (usually up to 12 hours from the first dose of rocuronium)

    Blood sample from the patients when patient shows allergic reaction after administration of rocuronium

Sponsors and collaborators

Lead sponsor

Seoul National University Hospital

Other

Registry information

Official study title

High Dimensional Analysis of Immune Cells Using scRNA-seq in Pediatric Patients With Allergic Reactions to Neuromuscular Blockers

Important dates

Study start
2023
Primary completion
2026
Study completion
2026
First posted
Apr 20, 2023
Registry last updated
Nov 29, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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