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Completed

NCT Number: NCT05531903

High-density Activation Mapping of the Slow Pathwayto Guide Catheter Ablation in Patients With Typical Atrioventricular Nodal Reentrant Tachycardia

Atrioventricular nodal reentrant tachycardia (AVNRT) is the most common supraventricular tachycardia inducible during an electrophysiological study. Although ablative therapy proved to be the treatment of choice, little is known about the components of the tachycardia circuit. The aim of this study is to detect the presence and patterns of specific electrograms representing slow pathway (SP) potentials and to explore Koch's triangle pattern activation during sinus rhythm and/or atrial extraestimulus with a high-density mapping catheter in an attempt to clarify a fast and safety catheter ablation strategy. We hypothesized that, in patients with dual atrioventricular nodal physiology, during sinus rhythm (SR), high-density mapping (HDM) catheters could identify the SP signals, making possible to delineate small areas of slow conduction associated to abnormal electrograms on Koch's triangle. On a second step, radiofrequency (RF) applications safety guided by the HDM obtained with this method, should interrupt the circuit far from the His region. Finally, SP signals should disappear after the RF procedure when performing a new 3D HDM. A control group of patients without AVN dual physiology should show absence of fragmented/slow conduction zones.

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Key information

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients > 18 yo with AVNRT observed after electrophysiological study

Exclusion criteria

  • Patients < 18 yo

Treatment and study plan

Description of Slow pathway signals to facilitate ablation

Device

3D endocardial mapping in order to identify slow pathway signals and abolish or modificate them after radiofrequency ablation

Primary outcomes

  1. Absence of reinduction of AVNRT after abolition of fragmented/slow conduction signals

    Time frame: one day

    Number of patients with absence of fragmented/slow conduction signals observed during sinus rhythm or atrial pacing after radiofrequency application

Secondary outcomes

  1. Absence of AVNRT relapses

    Time frame: one month

    Number of patients with absence of relapses after 1 month of the electrophysiological study

  2. Percentage of patient without AVNRT reinduction after procedure

    Time frame: One day

    Percentage of patients without tachycardia induction after radiofrequency applications protocol

Sponsors and collaborators

Lead sponsor

Parc de Salut Mar

Other

Registry information

Official study title

High-density Activation Mapping of the Slow Pathway During Sinus Rhythm: a New and Simple Method to Guide Catheter Ablation in Patients With Typical Atrioventricular Nodal Reentrant Tachycardia

Important dates

Study start
2022
Primary completion
2023
Study completion
2023
First posted
Sep 8, 2022
Registry last updated
Apr 12, 2024

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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