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NCT Number: NCT07611903

HFNC Versus Microstream Advance Nasal Cannula for Oxygenation During ERCP

Endoscopic retrograde cholangiopancreatography (ERCP) procedures are commonly performed under deep sedation and are associated with a risk of hypoxemia, particularly in prone or semi-prone positions. High-flow nasal cannula (HFNC) therapy may improve oxygenation by delivering heated and humidified oxygen at high flow rates, while the Microstream Advance nasal cannula provides simultaneous nasal oxygen delivery and oral oxygen insufflation.

This prospective randomized study aims to compare the effectiveness of HFNC and Microstream Advance nasal cannula in maintaining oxygenation during ERCP procedures. Patients undergoing ERCP will be randomized into two groups receiving either HFNC or Microstream Advance nasal cannula oxygen support during sedation.

The primary outcomes are the incidence of desaturation and oxygen reserve index (ORi) measurements during the procedure. Secondary outcomes include time to achieve target ORi levels, respiratory complications, and procedure-related adverse events.

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Key information

Conditions

Endoscopic Retrograde Cholangiopancreatography Hypoxemia Hypoxia Pathological Conditions, Signs and Symptoms Signs and Symptoms Signs and Symptoms, Respiratory

Age range

18 year–84 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kocaeli University Faculty of Medicine Hospital

Kocaeli, Umuttepe, 41100, Turkey (Türkiye)

Location status: Recruiting

Location contact

Volkan Alparslan, M.D.

CONTACT

[email protected]

05059374578

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients aged 18 to 84 years
  • ASA physical status I-III
  • Patients scheduled to undergo ERCP
  • Patients who provide written informed consent

Exclusion criteria

  • Recent history of upper respiratory tract infection
  • History of lung cancer
  • Chronic obstructive pulmonary disease
  • Asthma
  • Body mass index greater than 35 kg/m²
  • Refusal to participate in the study

Treatment and study plan

High-flow nasal canula

Device

Heated and humidified high-flow oxygen therapy delivered through a nasal cannula during ERCP under sedation

Microstream advance nasal cannula

Device

Oxygen support delivered through the Microstream Advance nasal cannula during ERCP under sedation.

Primary outcomes

  1. Incidence of Desaturation During ERCP

    Time frame: During the ERCP procedure

    Comparison of the frequency of oxygen desaturation episodes between HFNC and Microstream Advance nasal cannula groups during ERCP under sedation.

Study contacts

Contact information is provided by the study sponsor or research team.

Volkan Alparslan, M.D.

CONTACT

[email protected]

05059374578

Sponsors and collaborators

Lead sponsor

Kocaeli University

Other

Registry information

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
May 28, 2026
Registry last updated
Jul 15, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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