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OpenTrials
Completed

NCT Number: NCT04982341

HFNC and Prone Positioning in Awake Patients With Severe COVID-19

The investigators evaluate the effects of High-flow nasal cannula (HFNC) in association with prone in patients with Covid-19 severe ARF.

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Key information

Conditions

Hypoxemic Respiratory Failure Respiration Disorders Respiratory Insufficiency Respiratory Tract Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

CHU F.Bourguiba

Monastir, 5000, Tunisia

About this study

The investigators evaluate the effects of High-flow nasal cannula (HFNC) in association with prone in patients with Covid-19 severe ARF.

All patients with ARF related to Covid-19 and admitted to the ICU are turned in prone position whenever tolerated, while receiving oxygenation with HFNC.

Outcomes of interest are the rate of success or failure (defined as the need for intubation and mechanical ventilation)

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • aged ≥18 years, admitted to the medical ICU for confirmed Covid-19 and acute hypoxemic respiratory failure

Exclusion criteria

  • patients already intubated at admission or those requiring immediate intubation

Treatment and study plan

prone position

Procedure

patients are returned from prone to supine position while receiving oxygenation through HFNC

Primary outcomes

  1. Number of patients without intubation

    Time frame: through study completion, an average of 28 days

    successful oxygenation without intubation

Sponsors and collaborators

Lead sponsor

Hôpital Universitaire Fattouma Bourguiba

Other

Registry information

Official study title

Effectiveness of High-flow Nasal Cannula and Prone Positioning in Awake Patients With COVID-19 and Severe Acute Respiratory Failure

Important dates

Study start
2020
Primary completion
2021
Study completion
2021
First posted
Jul 29, 2021
Registry last updated
Jul 29, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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