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Completed

NCT Number: NCT03903237

Herpes Zoster: Risk Factors, Complications and Special Situations

This retrospective analysis is to investigate patients' history and clinical presentation in Herpes Zoster (HZ), Zoster-related complications, post-Zoster neuralgia and Herpes Zoster management in order to improve the management of HZ patients, to refine HZ-vaccination strategies and elucidate cost factors of HZ in in the setting of a university hospital in Switzerland generally and in a dermatology department specifically.

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Key information

Conditions

Herpes Zoster DNA Virus Infections Herpesviridae Infections Infections Nervous System Diseases Neuralgia Neuralgia, Postherpetic Neurologic Manifestations Neuromuscular Diseases Pain Pathological Conditions, Signs and Symptoms Peripheral Nervous System Diseases Signs and Symptoms Varicella Zoster Virus Infection Virus Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Department of Dermatology, University Hospital Basel

Basel, 4031, Switzerland

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Reports of patients with HZ at University Hospital Basel between 2004-2018

Exclusion criteria

  • rejection to use patient data

Treatment and study plan

Retrospective Chart Review

Other

retrospective report review of HZ patients treated between 2005 and 2018 in the Department of Dermatology at the University Hospital Basel

Primary outcomes

  1. Evaluation of patients' history

    Time frame: single time point assessment at baseline

    Free text evaluation of patients' history (age, sex, comorbidities, immunosuppression, obesity, human immune deficiency Virus (HIV), profession, current medication, vaccinations, seasonal occurence of HZ, history of Varicella Zoster virus (VZV) infection

  2. Description of the clinical presentation of HZ

    Time frame: single time point assessment at baseline

    Free text description of the clinical presentation of HZ (localisation, dermatomes affected), Zoster-related acute pain

  3. Evaluation of zoster-related complications

    Time frame: single time point assessment at baseline

    Free text evaluation of zoster-related complications (ophthalmic zoster, generalised HZ, Ramsay-Hunt syndrome, zoster meningoencephalitis)

  4. Evaluation of the herpes zoster management

    Time frame: single time point assessment at baseline

    Free text evaluation of the herpes zoster management (local (antiviral) treatment, systemic antiviral and other treatments, number of revisits, average treatment-related costs, hospitalisations (rate, duration)

  5. Assessment of post-zoster neuralgia

    Time frame: single time point assessment at baseline

    Free text assessment of post-zoster neuralgia (annual incidence, treatment options used)

  6. Evaluation of zoster and pregnancy

    Time frame: single time point assessment at baseline

    Free text evaluation of zoster and pregnancy (incidence, time of pregnancy, pregnancy outcomes and complications)

Sponsors and collaborators

Lead sponsor

University Hospital, Basel, Switzerland

Other

Registry information

Official study title

Herpes Zoster: Risk Factors, Complications and Special Situations- a Retrospective Analysis

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Apr 4, 2019
Registry last updated
Apr 4, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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