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Completed

NCT Number: NCT03789565

Hepcidin Levels in Periodontal Health and Disease

Periodontal disease refers to inflammatory disease of the periodontium caused by the host and/or pathogenic microorganisms. Anti-inflammatory and pro-inflammatory cytokines play a role in the periodontal inflammation process. The aim of this study was to evaluate the levels of hepcidin, interleukin (IL)-6, and IL-10 levels in gingival crevicular fluid (GCF) and in serum samples obtained from individuals with periodontal inflammation.

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Key information

Conditions

Periodontal Diseases Mouth Diseases Stomatognathic Diseases

Age range

32 year–52 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Çiğdem Coşkun Türer

Zonguldak, 67600, Turkey (Türkiye)

About this study

The study included 90 individuals, who were divided into three groups: periodontally healthy (PH) (n=30); gingivitis (G) (n=30); and chronic periodontitis (CP) (n=30). GCF and serum samples were obtained from each individual, and samples were evaluated using ELISA. Statistical evaluation of the data was performed using the SPSS packet data program.

Who can participate

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Systematically healthy patients. Patients who did not receive any medication or periodontal treatment within the previous 6 months

Exclusion criteria

  • Individuals who smoked and women who were pregnant and/or lactating were excluded from the study

Treatment and study plan

Biomarker test

Other

Diagnostic biomarker study

Primary outcomes

  1. Hepcidin levels

    Time frame: 1 year

    Change in inflammatory phases

Secondary outcomes

  1. IL-6 levels

    Time frame: 1 year

    Change in inflammatory phases

  2. IL-10 levels

    Time frame: 1 year

    Change in inflammatory phases

Sponsors and collaborators

Lead sponsor

Bulent Ecevit University

Other

Registry information

Official study title

Gingival Crevicular Fluid and Serum Levels of Hepcidin, IL-6 and IL-10 in Periodontal Health and Disease

Important dates

Study start
2017
Primary completion
2018
Study completion
2018
First posted
Dec 28, 2018
Registry last updated
Oct 4, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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