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OpenTrials
Completed

NCT Number: NCT01634438

Heparin Dose for Radial Angiography

At present, coronary angiogram is usually performed either through an artery in your groin or wrist. An important limitation of the wrist approach is an increase rate of blockage of the wrist artery. It is possible that the dose of blood thinner (i.e. heparin) may decrease the risk of blockage. Early studies seem to suggest that higher dose is required to reduce the risk of this important complication. However, to date there has not been a definitive study to determine the most appropriate heparin dose for the prevention of this complication. The main goal of this study is to determine the appropriate heparin dose to prevent wrist artery blockage and to determine risk factors for developing such a complication.

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Key information

Conditions

Coronary Angiograph

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Mazankowski Alberta Heart Institute

Edmonton, Alberta, T6G2B7, Canada

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients older than 18 years of age who were referred for either urgent or elective cardiac catheterization were eligible for the study if a normal Allen's test was demonstrated

Exclusion criteria

  • myocardial infarction with shock,
  • ST-elevation myocardial infarction,
  • patients undergoing planned percutaneous coronary intervention, and
  • patients in whom transradial approach is contraindicated such as hemodialysis patients

Treatment and study plan

Unfractionated heparin

Drug

unfractionated heparin

Primary outcomes

  1. radial artery occlusion

    Time frame: one month

    The primary endpoint was radial artery occlusion defined as absence palpable radial artery with no flow as assessed by Doppler study

Sponsors and collaborators

Lead sponsor

University of Alberta

Other

Registry information

Official study title

Low Versus High Dose Unfractionated Heparin in Patients Undergoing Angiography Via the Radial Artery

Important dates

Study start
2008
Primary completion
2010
Study completion
2010
First posted
Jul 6, 2012
Registry last updated
Jul 6, 2012

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.