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OpenTrials
Completed

NCT Number: NCT04146493

Heparin-Binding Protein and Heparins

Heparin-Binding protein is a protein from primary and secretory granluae of white blood cells. It is released when white blood cells become activated and has been advocated as a biomarker for sepsis. The aim of this study is to find out if Heparins in clinical doses can change the level of Heparin-binding protein in plasma.

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Key information

Conditions

Vascular Disease, Peripheral Cardiovascular Diseases Peripheral Vascular Diseases Thromboprophylaxis Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Halla Halldorsdottir

Stockholm, Solna, 17176, Sweden

About this study

Blood samples are taken from patients before and after Heparins in clinical doses. The effects of heparins on Heparin-binding protein concentration in plasma is measured. This is a small observational study.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Planned endovascular treatment of aortic aneurysm or peripheral vascular surgery where unfractionated heparin in >3000 units are given perioperatively
  • Planned subcutaneous low molecular weight heparin as a thromboprophylactic treatment after major surgery or on Intensive Care treated patients.
  • Planned open heart surgery with cardiopulmonary bypass.

Exclusion criteria

  • Under 18 years
  • Unable to get informed consent from patient or relative

Treatment and study plan

Blood samples for Heparin-binding protein measurement

Diagnostic Test

Blood samples before and after given heparin

Primary outcomes

  1. Changes in the level of Heparin-binding protein

    Time frame: Repeated blood sampling during minimum of 1 hour and maximum of 5 hours after given heparin

    Blood samples are taken before and after given heparin

Sponsors and collaborators

Lead sponsor

Halla Halldorsdottir

Other

Collaborators

  • Karolinska Institutet

Registry information

Acronym: HepHep

Important dates

Study start
2019
Primary completion
2021
Study completion
2021
First posted
Oct 31, 2019
Registry last updated
Nov 18, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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