Hemostatic Powder Following Injection Therapy Versus Conventional Dual Therapy for Endoscopic Hemostasis for Non-variceal Upper Gastrointestinal Bleeding

Patients with upper GI bleeding who need endoscopic hemostasis will be enrolled in this study. When there is a upper GI bleeding with active bleeding or stigmata on the lesions, endoscopic hemostasis will be done.

After randomization, patients in both group will undergo endoscopic hemostasis with epinephrine injection therapy. In the study group, Endo-clot will be applied after epinephrine injection therapy. In the control group, hemoclip will be applied after epinephrine injection therapy. The efficacy of Endo-Clot and hemoclip will be compared.

Inclusion criteria

• Older than 19 years old
• Patients with hematemesis, hematochezia, melena, suspected upper gastrointestinal bleeding
• Inpatients who were consulted gastroenterologist for management of upper gastrointestinal bleeding
• Patients who are planned to undergo EGD for management of upper gastrointestinal bleeding

Exclusion criteria

• Patients who had diagnosed esophageal cancer or stomach cancer
• Patients who are suspected variceal bleeding, had medical history of liver cirrhosis, hepatocellular carcinoma
• Coagulation disorder (hemophilia, ITP,,)
• Post-procedure bleeding (EGD biopsy, EMR, ESD, stent insertion..)
• Patients who cannot undergo EGD because of anatomical problem, unconsciousness.
• Patients who are unwilling or unable to provide informed consent, such as those with psychiatric problem, drug abuse or alcoholism