Hemostatic Endothelial Dysfunction in Patients With Peripheral Artery Disease

The study will involve patients with atherosclerotic peripheral artery disease (Rutherford category 3-5). The subjects are to be divided into three groups:

Group A: patients who undergo bypass surgery with a synthetic graft on aorto-iliac or femoro-popliteal segment; Group B: patients who undergo endovascular balloon angioplasty and stenting on aorto-iliac or femoro-popliteal segment; Group C: patients who undergo standard of care conservative treatment.

Decisions on revascularization or conservative treatment alone is to be made by a team of vascular specialists in accordance with the severity of the disease, previous treatment, anatomy, possible need for repeat procedures in the future, and patient's preferences.

Inclusion criteria

• Males or females older than 40 years of age;
• Presence of peripheral arterial disease of atherosclerotic origin.

Exclusion criteria

• Males or females younger than 40 years of age;
• Chronic lower limb ischemia of other ethiology (Buerger's disease, aortoarteritis etc.);
• Active cancer or remission period less than 5 years;
• Decompensated diabetes mellitus;
• Pregnancy or breast-feeding for females.