Skip to main content
OpenTrials
Completed

NCT Number: NCT05872308

Hemorrhagic Myocardial Infarction Detection by Post-reperfusion Troponin Kinetics

Pilot trial to determine diagnostic efficacy of post-reperfusion troponin kinetics in detection of hemorrhagic myocardial infarction

Completed

Looking for future studies?

Notify Me

Key information

Conditions

Acute Myocardial Infarction Cardiovascular Diseases Heart Diseases Infarction Ischemia Myocardial Infarction Myocardial Ischemia Necrosis Pathologic Processes Pathological Conditions, Signs and Symptoms ST Elevation Myocardial Infarction Vascular Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Synergy Cardiovascular Research Center, Synergy Superspecialty Hospital, Rajkot, Gujarat, India

Loading trial locations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Age ≥ 18 years
  • Index STEMI
  • Coronary angiogram with PCI to occur irrespective of the onset of the symptoms.
  • Ability to provide informed consent for themselves

Exclusion criteria

  • History of prior myocardial infarction,
  • Cardiogenic shock,
  • Patients who present with current cardiac arrest
  • Any contraindication to cardiac CMR (claustrophobia, pacemaker or cardiac defibrillator, known allergy to gadolinium),
  • Presence of permanent atrial fibrillation,
  • Unconscious patient,
  • Severe renal insufficiency (creatinine clearance ≤ 30 ml/min/m2 or renal replacement therapy),
  • Women who are pregnant or breastfeeding. Women of reproductive potential must have a negative pregnancy test.

Treatment and study plan

Primary outcomes

  1. Diagnostic Threshold

    Time frame: 48 hours

    Levels of markers in hemorrhagic infarct vs. non-hemorrhagic infarct

Secondary outcomes

  1. Peak levels of serum troponin-I

    Time frame: 48 hours

    peak levels of serum troponin-I in hemorrhagic infarct vs non-hemorrhagic infarct

  2. Area under the curve (AUC) for serum troponin-I

    Time frame: 48 hours

    area under the curve post-MI for troponin-I

  3. Hemorrhagic infarct size

    Time frame: 48 hours

    as determined by cardiac MRI

  4. Hemorrhagic infarct volume

    Time frame: 48 hours

    as determined by cardiac MRI

  5. Hemorrhagic infarct microvascular obstruction

    Time frame: 48 hours

    as determined by cardiac MRI

  6. Hemorrhagic infarct area at risk

    Time frame: 48 hours

    as determined by cardiac MRI

Sponsors and collaborators

Lead sponsor

Rohan Dharmakumar

Other

Registry information

Official study title

Hemorrhagic Myocardial Infarction Detection With High-sensitivity Cardiac Troponin-I

Acronym: MIRON-TROP

Important dates

Study start
2022
Primary completion
2025
Study completion
2025
First posted
May 24, 2023
Registry last updated
Sep 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Related clinical trials

Published trials that share one or more normalized conditions with this study.