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Completed

NCT Number: NCT03570164

Hemodynamics for Equi-MAC Anesthesia

The aim of this study is to compare the peripheral perfusion index values produced by equi-MAC of sevoflurane and desflurane in patients undergoing single-agent inhalation anesthesia.

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Key information

Conditions

Anesthesia

Age range

19 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Kangbuk Samsung Hospital

Seoul, 03181, South Korea

About this study

Ether derivative anesthetics, including sevoflurane and desflurane, have direct activity on vascular tissue and both are vasodilators. However, there has been no direct comparison of vasodilative effect between sevoflurane and desflurane in vivo in humans. Peripheral perfusion index derived from photoplethysmographic waveform reflects peripheral vasomotor tone. Therefore, the purpose of this study is to compare the peripheral perfusion index values produced by sevoflurane and desflurane at equipotent concentration in patients undergoing single-agent inhalation anesthesia.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • patients aged between 19 and 65 yr
  • patients with American Society of Anesthesiologists physical status classification I or II
  • patients scheduled for elective arthroscopic knee surgery under general anesthesia
  • patients obtaining written informed consent

Exclusion criteria

  • patients with a history of any disease associated with the autonomic nervous system
  • patients receiving any medication affecting the sympathetic or parasympathetic nervous systems
  • patients with cardiac arrhythmia, diabetes mellitus, and alcohol or drug abuse
  • pregnant women

Treatment and study plan

Sevoflurane

Drug

End-tidal concentration of sevoflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.

Other names: Sevorane

Desflurane

Drug

End-tidal concentration of desflurane is maintained at age-corrected 1.0 minimum alveolar concentration throughout the study period.

Other names: Suprane

Primary outcomes

  1. peripheral perfusion index

    Time frame: After a 30-min waiting period from the induction of anesthesia

    peripheral perfusion index value at a steady-state anesthesia of age-corrected 1.0 MAC

Secondary outcomes

  1. mean arterial pressure

    Time frame: After a 30-min waiting period from the induction of anesthesia

    mean arterial pressure at a steady-state anesthesia of age-corrected 1.0 MAC

  2. heart rate

    Time frame: After a 30-min waiting period from the induction of anesthesia

    heart rate at a steady-state anesthesia of age-corrected 1.0 MAC

Sponsors and collaborators

Lead sponsor

Kangbuk Samsung Hospital

Other

Registry information

Official study title

Comparison of Vasodilative Effects Between Sevoflurane and Desflurane Using Peripheral Perfusion Index

Important dates

Study start
2018
Primary completion
2018
Study completion
2018
First posted
Jun 26, 2018
Registry last updated
Oct 21, 2019

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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