Hemodynamic Study of In-Stent Stenosis(I) After Flow Diverter(F) Based on 3D-DSA(D) Combined With TCCD(T)

Primary outcomes

1. operative Hemodynamic Differences ### Pre- and Post-operative Hemodynamic Differences ### Pre- and Post-operative Hemodynamic Differences ### Pre- and Post-operative Hemodynamic Differences ### Pre- and Post-operative Hemodynamic

   Time frame: Preoperatively, 3 days postoperatively, and 6 months postoperatively

   Transcranial Color-Coded Doppler (TCCD) measurements of blood flow velocity

2. Hemodynamic changes in-stent stenosis

   Time frame: Preoperatively, 3 days postoperatively, and 6 months postoperatively

   Transcranial Color-Coded Doppler (TCCD) measurements of blood flow velocity

3. The occlusion rate of the aneurysm

   Time frame: 6 months

   The occlusion rate of the aneurysm at 6 months

4. Proportion of patients without disability at 6 months

   Time frame: 6 months

   mRS score 0-1

5. Proportion of patients with functional independence at 6 months

   Time frame: 6 months

   mRS score 0-2

6. Proportion of patients with Symptomatic intracranial hemorrhage(sICH) within 48 hours

   Time frame: Within 48 hours

   ICH will be evaluated according to the Heidelberg Bleeding Classification. sICH is diagnosed if the new observed ICH is associated with any of the following conditions: 1) NIHSS score increased more than 4 points than that immediately before worsening; 2) NIHSS score increased more than 2 points in one category; 3) Deterioration led to intubation, hemicraniectomy, external ventricular drain placement or any other major interventions. Additionally, the symptom deteriorations could not be explained by causes other than the observed ICH.

7. Incidence of serious adverse events

   Time frame: Within 1 years

   Including but not limited to acute respiratory failure, severe or malignant cerebral artery infarction, acute heart failure, debridement decompression, and other major medical events that can result in death, immediately life-threatening, hospitalization or prolongation of this hospitalization, terminally or severely disabling/incapacitating, the loss of a significant ability to maintain normal life functioning, or medical intervention to avoid the above outcomes.

8. Procedure-related complications Procedure-related complications

   Time frame: Up to 24 hours

   such as arterial perforation, iatrogenic arterial dissection, embolization in previously uninvolved vascular territory, arterial access site hematoma, and retroperitoneal hematoma. Arterial perforation will be defined at angiography by the operator and associated with subarachnoid hemorrhage. Iatrogenic arterial dissection will be defined at angiography by the operator. Arterial access site hematoma will be assessed as a complication of arterial access puncture and defined by clinical examination and anatomic imaging. Retroperitoneal hematoma will be assessed as a complication of groin puncture and defined by imaging (ultrasound or CT or MR angiography). The definition of embolization in previously uninvolved vascular territory is noted after recanalization of the primary occlusion site, any vessel occlusions distal from the primary occlusion site are considered emboli due to periprocedural thrombus fragmentation.