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OpenTrials
Completed

NCT Number: NCT00682110

Hemodynamic Measurements During Liver Transplantation

The purpose of the study is to determine if the less invasive monitors are as reliable for measuring heart function in patients undergoing liver transplantation as the more invasive pulmonary artery.

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Key information

Conditions

Liver Transplantation Digestive System Diseases End Stage Liver Disease Hepatic Insufficiency Liver Diseases Liver Failure

Age range

18 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Washington University School of Medicine

St Louis, Missouri, 63110, United States

About this study

Pulmonary artery catheter (PAC)is considered the gold standard in monitoring of heart function during orthotopic liver transplantation (OLT). Placement of PAC is very invasive (it passes thorough the heart chambers and into the pulmonary artery) and its benefits on the outcomes have not been proven. This study compares two newer FDA approved much less invasive devices to the PAC. The two new devices assess the heart function based either on the peripheral arterial waveform alone (Vigileo, Edwards Lifesciences)or the combination of peripheral arterial waveform and chemical indicator dilution (LiDCO, Cambridge, UK).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients over 18 years of age
  • Scheduled for liver transplantation
  • Patient undergoing vascular surgery where invasive arterial pressure is indicated (control subjects)

Exclusion criteria

  • We will exclude patients taking lithium based medication
  • Patients who weigh less than 40 kg; AND
  • Patients who are pregnant

Treatment and study plan

Primary outcomes

  1. Agreement between cardiac output measurements obtained with PAC, Vigileo and LiDCO

    Time frame: Specific phases of liver transplantation surgery

Sponsors and collaborators

Lead sponsor

Washington University School of Medicine

Other

Registry information

Official study title

Comparing Different Methods For Measurement of Cardiac Output During Orthotopic Liver Transplantation

Acronym: OLT

Important dates

Study start
2007
Primary completion
2009
Study completion
2010
First posted
May 22, 2008
Registry last updated
Apr 1, 2010

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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