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Completed

NCT Number: NCT02056821

Hemodynamic Effects on Cerebral Autoregulation in Acute Stroke

This study investigates if there are hemodynamic alterations in acute stroke that predispose patients to impaired perfusion and regulation of cerebral blood flow. To test this, we will target recruitment of acute ischemic stroke patients who present to the ED within 12 hours of symptoms onset. Enrolled subjects will receive continuous noninvasive hemodynamic monitoring contemporaneous with measurements of cerebral blood flow velocities and cerebral oximetry.

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Key information

Conditions

Ischemic Stroke Brain Diseases Cardiovascular Diseases Central Nervous System Diseases Cerebrovascular Disorders Nervous System Diseases Stroke Vascular Diseases

Age range

18 year–90 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Henry Ford Hospital

Detroit, Michigan, 48202, United States

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Suspected ischemic stroke within 12 hours of symptom onset
  • NIHSS ≥ 4
  • Age 18 to 90 years

Exclusion criteria

  • Baseline modified Rankin Scale > 3
  • Pregnancy
  • Intracranial hemorrhage on head CT
  • Mechanical ventilation prior to enrollment
  • Inadequate temporal windows for TCD analysis

Treatment and study plan

Primary outcomes

  1. Change in cerebral blood flow velocities

    Time frame: initial 24 hours

    Cerebral flow velocities determined by bilateral MCA measurements by TCD

Sponsors and collaborators

Lead sponsor

Henry Ford Health System

Other

Collaborators

  • Wayne State University

Registry information

Important dates

Study start
2014
Primary completion
2016
Study completion
2016
First posted
Feb 6, 2014
Registry last updated
Jan 4, 2017

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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