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OpenTrials
Completed

NCT Number: NCT04212559

Hemodynamic Effects of Negative Pressure Ventilation in Chronic Obstructive Pulmonary Disease

Negative pressure ventilation (NPV) is a non-invasive ventilation mode which provide better lung expansion. The major complication of NPV is decrease blood pressure and affects the hemodynamics. The effects of NPV on chronic obstructive pulmonary disease (COPD) patients with pulmonary rehabilitation program remains unknown.

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Key information

Conditions

COPD Chronic Disease Disease Attributes Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases

Age range

20 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Fu Jen Catholic University Hospital, Fu Jen Catholic University

New Taipei City, 24352, Taiwan

About this study

Both of NPV or positive pressure ventilation (PPV) has impact of hemodynamics. NPV with cuirass ventilator increases venous return and leads to ventricular filling and increases cardiac output (CO); In contrast to NPV, the effect of PPV in most situations is a decreased venous return and leads to decreased CO. NPV improving ventilation and work of breathing in patients with chronic obstructive pulmonary disease (COPD).

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Patients with COPD who received pulmonary rehabilitation program with NPV treatment

Exclusion criteria

  • Recent exacerbation within 3-months
  • Existing of tracheostomy
  • Absence of NPV used
  • Required of oxygen supplement during NPV
  • Diagnosed of neuromuscular disease

Treatment and study plan

Received negative pressure ventilation

Other

Patients who received a negative pressure during inspiratory phase.

Primary outcomes

  1. CO (cardiac output)

    Time frame: 20 minutes

    Change of Cardiac output before and after NPV treatment

  2. SV (stroke volume)

    Time frame: 20 minutes

    Change of stroke volume before and after NPV treatment

Secondary outcomes

  1. SpO2

    Time frame: 20 minutes

    Change of oxygen saturation before and after NPV treatment

  2. RR (respiratory rate)

    Time frame: 20 minutes

    Change of respiratory rate before and after NPV treatment

Sponsors and collaborators

Lead sponsor

Fu Jen Catholic University

Other

Registry information

Official study title

Hemodynamic Effects of Negative Pressure Ventilation in Chronic Obstructive Pulmonary Disease Assessed Using Non-Invasive Electrical Cardiometry

Important dates

Study start
2018
Primary completion
2019
Study completion
2019
First posted
Dec 27, 2019
Registry last updated
Jan 18, 2020

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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