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OpenTrials
Completed

NCT Number: NCT01939509

Hemodynamic Changes of Patients Receiving Atenolol/Bisoprolol

At hemodynamic level, the greater affinity of bisoprolol by the beta 1 receptor in theory could improve the peripheral arterial perfusion and could have a greater antihypertensive effect. At the same time, this could carry objectifiable improvements in the vascular tree, such as the level of arterial stiffness.

This study attempts to mark the hemodynamic differences in the same individual with hypertension and metabolic syndrome who will be exposed to both drugs at different moments. Parameters will be objectified with impedance cardiography, pulse wave velocity and central blood pressure assessment before and after taking each one of the drugs. The results will be compared to the baseline data and between themselves.

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Key information

Age range

21 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Hospital Italiano de Buenos Aires, Buenos Aires, Argentina

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Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Hypertension
  • Metabolic syndrome

Exclusion criteria

  • Severe hypertension >180/110
  • Secondary hypertension
  • Contraindication for betablockers
  • Prior treatment with betablockers (up to one month before inclusion)
  • History of neoplastic disease
  • Patients that do not sign informed consent

Treatment and study plan

Atenolol

Drug

Crossover (atenolol 25-50 mg, bisoprolol 2.5-5 mg)

Bisoprolol

Drug

Primary outcomes

  1. central blood pressure

    Time frame: two months

Secondary outcomes

  1. peripheral resistance

    Time frame: two months

  2. cardiac index

    Time frame: two months

  3. pulse wave velocity

    Time frame: two months

Sponsors and collaborators

Lead sponsor

Hospital Italiano de Buenos Aires

Other

Registry information

Official study title

Comparison of the Hemodynamic Changes in Patients Under Treatment With Bisoprolol Versus Atenolol

Acronym: CHAB

Important dates

Study start
2012
Primary completion
2014
Study completion
2014
First posted
Sep 11, 2013
Registry last updated
Dec 5, 2014

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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