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OpenTrials
Completed

NCT Number: NCT02442232

Hemodynamic Changes After Anesthesia With Propofol: Study of Biomarkers

The purpose of this study is to evaluate biomarkers affecting the hemodynamic responses to propofol. Particularly, the investigators will assess the effects of polymorphisms in NOS3 and PRKCA genes on hemodynamic responses to propofol and the effects of these polymorphisms on biomarkers related to nitric oxide after propofol anesthesia. In addition, the investigators will evaluate the effects of propofol anesthesia on biomarkers related to nitric oxide in hypertensive patients chronically treated with angiotensin-converting enzyme inhibitors.

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Key information

Conditions

Hemodynamic Responses to Propofol

Age range

40 year–80 year

Sex eligibility

All sexes

Study type

Observational

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • ASA I or II
  • BMI lower 30 kg/m2

Exclusion criteria

  • Severe hypertension
  • Previous stroke
  • Previous infarction
  • Uncontrolled respiratory, renal, hepatic and hematological diseases.

Treatment and study plan

Primary outcomes

  1. Systolic blood pressure

    Time frame: 10 minutes

  2. Diastolic blood pressure

    Time frame: 10 minutes

  3. Mean blood pressure

    Time frame: 10 minutes

  4. Heart rate

    Time frame: 10 minutes

  5. Plasma nitrite levels

    Time frame: 10 minutes

  6. Plasma nitrate levels

    Time frame: 10 minutes

Sponsors and collaborators

Lead sponsor

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Other Gov

Registry information

Important dates

Study start
2015
Primary completion
2015
Study completion
2016
First posted
May 13, 2015
Registry last updated
Aug 26, 2016

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.