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NCT Number: NCT06910449

Hemithoracic Arc Radiotherapy Post Pleural Decortication

Malignant Pleural Mesothelioma is an aggressive and refractory disease , the most aggressive treatment plan offered to these patients include trimodalitiy approach with chemotherapy as the mainstay of treatment . the rationale of post operative Radiotherapy is to sterilize the post operative volume to reduce local failure meanwhile minimizing toxicities in this trial we are going to assess the safety and efficacy of Radiotherapy in Mesothelioma patients poat Pleural decortication

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Key information

Conditions

Malignant Pleural Mesothelioma Adenoma Lung Diseases Lung Neoplasms Mesothelioma Mesothelioma, Malignant Neoplasms Neoplasms by Histologic Type Neoplasms by Site Neoplasms, Glandular and Epithelial Neoplasms, Mesothelial Pleural Neoplasms Respiratory Tract Diseases Respiratory Tract Neoplasms Thoracic Neoplasms

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

national Cancer Institute Cairo university

Cairo, Fom Elkhalig, 11796, Egypt

Location status: Recruiting

Location contact

Fom El khalig

CONTACT

[email protected]

20225328286

About this study

This study will include malignant Pleural Mesothelioma patients treated by trimodalitiy approach starting with neoadjuvant chemotherapy followed by surgery in the form of Pleural decortication then all patients will receive post operative hemithoracic radiation

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Evidence of metastatic disease.
  • Underwent Pleural decortication.
  • Able to provide informed consent.

Exclusion criteria

  • Poor pulmonary function tests.
  • Recurrent or palliative cases.
  • Inability to attend full course of Radiotherapy or follow up visits.

Treatment and study plan

hemithoracic Volumetric Arc Radiotherapy post Pleural decortication

Radiation

post operative delivery of hemithoracic Volumetric Arc Radiotherapy

Primary outcomes

  1. Acute Radiation Toxicity

    Time frame: weekly assessment during radiation course and monthly follow up for the first 6 months

    Questionnaire based Follow up about acute Radiation toxicity according to RTOG including dysnea , cough , chest pain , dysnea on effort from grade 1-5

  2. late radiation toxicity

    Time frame: Bi-monthly fashion of minimum 6 months post radiation course

    follow up of patients using both Questionnaire and performing pulmonary function tests and Echo , focusing on DLCO & FEV1

Study contacts

Contact information is provided by the study sponsor or research team.

Gamal

CONTACT

[email protected]

01000704731

Sponsors and collaborators

Lead sponsor

Cairo University

Other

Registry information

Official study title

Hemithoracic Volumetric Modulated Arc Radiotherapy as Part of Lung-Sparing Multimodality Therapy in Patients With Malignant Pleural Mesothelioma Phase II Trial

Important dates

Study start
2024
Primary completion
2026
Study completion
2027
First posted
Apr 4, 2025
Registry last updated
Apr 8, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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