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Completed

NCT Number: NCT00642447

Helium:Oxygen Noninvasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

to assess the effect of Heliox with Noninvasive positive pressure ventilation to decrease dyspnea and improve physiologic and respiratory measures in patients with a previous exposure to Sulfur Mustard gas.

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Key information

Conditions

Bronchiolitis Bronchial Diseases Bronchitis Bronchitis, Chronic Chronic Bronchitis Chronic Disease Disease Attributes Infections Lung Diseases Lung Diseases, Obstructive Pathologic Processes Pathological Conditions, Signs and Symptoms Pulmonary Disease, Chronic Obstructive Respiratory Tract Diseases Respiratory Tract Infections

Age range

38 year–59 year

Sex eligibility

Male

Study type

Interventional

Phase

Phase 2 / Phase 3

Primary location

BMSU

Tehran, Tehran Province, 19945-546, Iran

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • exposure to sulfur mustard
  • worsening dyspnea during the last 10 days
  • respiratory rate of >25/min
  • arterial pH<7.35
  • PaCO2 of >50 mmHg
  • PaO2 of <50 mmHg

Exclusion criteria

  • recent pneumothorax (<1 month)
  • severe respiratory failure or hemodynamic instability with forthcoming intubation
  • FIO2 of <0.4
  • impaired consciousness or absence of patient cooperation
  • facial lesions precluding NIPPV

Treatment and study plan

helium:oxygen mixture

Drug

Sponsors and collaborators

Lead sponsor

Baqiyatallah Medical Sciences University

Other

Registry information

Official study title

Helium:Oxygen Versus Air:Oxygen Nonivasive Positive Pressure Ventilation in Patients Exposed to Sulfur Mustard

Important dates

Study start
2007
First posted
Mar 25, 2008
Registry last updated
Mar 25, 2008

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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