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OpenTrials
Completed

NCT Number: NCT01759316

Heliox in Preterm Infants With Respiratory Distress Syndrome

Heliox can lower respiratory resistance, improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation.

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Key information

Conditions

Respiratory Distress Syndrome Lung Diseases Respiration Disorders Respiratory Tract Diseases

Age range

28 week–37 week

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Daping Hospital, China, Chongqing Municipality

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About this study

Heliox can improve the oxygenation, reduce respiratory distress and lung injury caused by mechanical ventilation.

Heliox has not been widely used. More studies on the effects and safety of Heliox in addition to NIPPV and mechanical ventilation should be tried.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Gestational age more than 28 weeks and less than 32 weeks
  • Diagnosed as respiratory distress syndrome
  • Need to use NIPPV ventilation
  • No congenital diseases or hereditary diseases
  • With an informed consent form

Exclusion criteria

  • With congenital diseases or hereditary diseases
  • Intubated in the delivery room
  • Need surgery

Treatment and study plan

Heliox

Other

heliox or oxygen is used in the two groups respectively

Primary outcomes

  1. length of ventilation and risk of mechanical ventilation

    Time frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks

    The primary outcome is the length of ventilation and risk of mechanical ventilation of participants.

Secondary outcomes

  1. Transcutaneous blood gas analysis，ventilator parameters and lung inflammation cytokines

    Time frame: participants will be followed for the duration of hospital stay, an expected average of 2 weeks

Sponsors and collaborators

Lead sponsor

Third Military Medical University

Other

Registry information

Official study title

Nasal Intermittent Positive Pressure Ventilation and Mechanical Ventilation With Heliox in Preterm Infants With Respiratory Distress Syndrome

Important dates

Study start
2012
Primary completion
2013
Study completion
2013
First posted
Jan 3, 2013
Registry last updated
Oct 28, 2013

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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