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Completed

NCT Number: NCT00922350

Heliox and Posture in Patients With Asthma

The purpose of this study is to verify that nebulization with bronchodilators associated with heliox gas (helium + oxygen) and the posture of a leaning forward truck is effective in patients with an asthma attack.

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Key information

Conditions

Acute Asthma Asthma Bronchial Diseases Hypersensitivity Hypersensitivity, Immediate Immune System Diseases Lung Diseases Lung Diseases, Obstructive Respiratory Hypersensitivity Respiratory Tract Diseases

Age range

18 year–65 year

Sex eligibility

All sexes

Study type

Interventional

Phase

Not applicable

Primary location

Barros Lima Policlinic

Recife, Pernambuco, Brazil

About this study

When associated with inhaled bronchodilators, the heliox, a mixture of helium and oxygen in obstructive lung diseases with asthma, reduces the turbulence of airflow despite high rates, due to its low density.

Although the first report of the use of heliox in the treatment of asthma dating to 1935, few controlled studies are available clarify the impact of the use of heliox in hospital admission of patients with acute asthma attacks refractory to standard treatment.

The severe airflow obstruction, observed in cases of acute asthma, also leads to lung hyperinflation that favors the increase of respiratory work by increasing the load for the inspiratory muscles by placing them at a mechanical disadvantage.

Various body positions were studied relating them to muscle activity with mechanical disadvantage. These studies suggest that the influence posture acts mainly in the position of the diaphragm, thus, increasing the stress related to other muscles such as the abdominals and the effect of gravity on these.

This study aims to: assess the efficiency of the positioning body associated with nebulization with bronchodilators carried by heliox during acute severe asthma in adults, using as the primary outcomes FEV1, FVC and PEF and secondary outcomes as the Borg scale, inspiratory capacity, RR, HR and SpO2.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • reversibility of bronchial obstruction after administration of bronchodilator drugs for at least 10% in FEV1
  • a clinical diagnosis of acute severe asthma
  • a history of asthma over 1 year
  • duration of the crisis of current asthma lasting less than seven days

Exclusion criteria

  • were unable to understand or perform the spirometric maneuver
  • smoking (within the last 3 years associated with a higher consumption of 100 cigarettes/year)
  • other pulmonary comorbidities
  • lower to upper airways
  • heart failure
  • heart rate greater than 150 bpm
  • systolic pressure below 90 mmHg or greater than 150 MHG
  • pregnancy
  • inability to stay inline with the trunk forward

Treatment and study plan

Heliox

Other

The nebulization was conducted in the same way that heliox + posture group, except the attitude of trunk, where the patients in this group did the Nebulizer with the trunk upright.

Other names: asma

Oxygen

Other

The NEBULIZATION was performed the same way as the heliox group, except for torso posture, where the patients in this group with the trunk upright Nebulizer Oxygen for cars have A NEBULIZATION.

Other names: ASTHMA, NEBULIZATION

HELIOX+POSTURE

Other

Patients underwent two carried by heliox nebulization associated with fenoterol (2.5 mg) and ipratropium bromide (0.25 mg). We used three ml of saline solution at 0.9%. For nebulization with heliox or oxygen, was used a system of distribution not invasive, semi-closed in a mask that is non toxic connected to a piece "Y" with a nebulizer in a follow and a bag of tank with a capacity for 2.5 L in the other connected with a valve action. This system was used so that there was a dilution gas. The proportion of 80:20 heliox was used (80% helium: 20% oxygen). To postural change in groups and heliox Oxygen + posture + posture, oriented to the participants to maintain an angle of inclination of the trunk and elbows supported on the thighs, measured from the anterior axillary line and lateral epicondyle of the femur, between 50th and 60th .

Other names: heliox, posture, physioterapy

OXYGEN + POSTURE

Other

The NEBULIZATION was conducted in the same way that heliox + posture GROUP, however the patients in this group have the Oxygen for Carr A NEBULIZATION

Other names: POSTURE, PHYSIOTERAPY, ASTHMA

Primary outcomes

  1. Spirometry

    Time frame: 6 months

Secondary outcomes

  1. Respiratory rate

    Time frame: 6 months

  2. Peripheral oxygen saturation

    Time frame: 6 months

  3. Borg scale

    Time frame: 6 months

  4. Heart rate

    Time frame: 6 months

Sponsors and collaborators

Lead sponsor

Universidade Federal de Pernambuco

Other

Registry information

Official study title

Heliox and Posture Optimize Action of Nebulization With Bronchodilators for Asthma Attacks. Randomized Trial.

Important dates

Study start
2008
Primary completion
2008
Study completion
2008
First posted
Jun 17, 2009
Registry last updated
Jun 17, 2009

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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