Helical Tomotherapy in Multiple Myeloma

This study is a single-center, prospective clinical study targeting myeloma patients requiring transplantation, and investigating the efficacy and safety of TBI combined with Mel regimen for transplant pretreatment. Subjects who meet the enrollment criteria were screened to enter the study and receive the corresponding regimen treatment.

Inclusion criteria

• Multiple myeloma patients receiving induction therapy and stem cell mobilization preparation for autologous transplantation;
• Should agree to comply with all contraceptive requirements; 3, ECOG≤2;

• Total bilirubin, ALT and AST <2×UNL (upper limit of normal), BUN < 30 mg/dL; 5. At least 2 x 10^6 CD34+ cells /kg were collected; 6.absolute neutrophil count >1000/uL and a platelet count of >100,000/uL; 7. The expected survival time is more than 3 months; 8. Written informed consent was obtained from the patients or their immediate family members.

Exclusion criteria

Any of the following was an exclusion criterion:

• According to the investigator's judgment, patients who cannot tolerate melphalan and radiotherapy;
• Patients with known active hepatitis B virus (HBV) or hepatitis C virus (HCV), or seropositive for human immunodeficiency virus (HIV);
• patients with uncontrolled or severe cardiovascular disease
• According to the protocol or the investigator's judgment, the patient has a serious physical or mental illness