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NCT Number: NCT00741728

Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population

The aim of the present Paris Prospective Study III (PPS3) is (1) to assess the determinants of the regulation of heart rate and blood pressure variations and carotid properties (under different physiologic stimulations) and (2) to evaluate the respective contribution of heart rate, blood pressure variations and carotid properties to cardiovascular morbidity and mortality including sudden death during 10 years at least in healthy considered subjects.

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This study is active but is not currently recruiting participants.

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Key information

Conditions

Community Based Study Blood Pressure Cardiovascular Disease Cardiovascular Diseases Death Death, Sudden Pathologic Processes Pathological Conditions, Signs and Symptoms Sudden Death

Age range

50 year–75 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Investigations Pré cliniques et Preventives de Paris

Paris, 75016, France

About this study

Overall, 10 157 men and women have been recruited during May 2008 and June 2012 for an extensive clinical examination including a 2h holter electrocardiography (ECG), a carotid doppler echo tracking, a step test, as well as blood and DNA collections. Since then, the cardiovascular morbidity and mortality of the participants is being followed up for 10 years at least and will continue up to 2032.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • 50-75 years, French speaking, given consent for genetic analysis,
  • written consent for participating in the study

Exclusion criteria

  • <50 years and >75 years,
  • no French speaking,
  • current pregnancy,
  • chronic severe disease,
  • disagreement for genetic analysis,
  • step test considered as non possible or non advisable by medical decision.

Treatment and study plan

Spider flash ECG, high-precision carotid echo-tracking, step test

Other

cardiac rhythm recorded during health check up, vascular aging parameters and baroreflex sensitivity recorded during carotid echotracking of the right common carotid artery , step test during 2 minutes

Primary outcomes

  1. cardiovascular disease (CVD)

    Time frame: through study completion, an average of 24 years

    incident coronary heart disease (CHD), stroke, sudden death, mortality

Secondary outcomes

  1. heart rate parameters and baroreflex sensitivity

    Time frame: 4 Years

    as measured on the Spider Flash ECG and the carotid echotracking

  2. other CVD outcomes

    Time frame: through study completion, an average of 24 years

    heart failure, arterial aneurysms, venous thromboembolism (VTE), pulmonary embolism, arrhythmic events (atrial fibrillation, flutter)

Sponsors and collaborators

Lead sponsor

Institut National de la Santé Et de la Recherche Médicale, France

Other Gov

Registry information

Official study title

Heart Rate, Baroreflex Sensitivity and Cardiovascular Morbidity and Mortality in the Population. The Paris Prospective Study III

Acronym: PPSIII

Important dates

Study start
2008
Primary completion
2032
Study completion
2032
First posted
Aug 26, 2008
Registry last updated
Feb 11, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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