Heart Function in Patients Assessed for Sleep Apnoea

This study aims to determine the prevalence and prognosis of heart failure with preserved ejection function (HFpEF) among patients being assessed for sleep disordered breathing (SDB).

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Key information

Conditions

Heart Failure With Preserved Ejection Fraction Apnea Cardiovascular Diseases Central Sleep Apnea Dyssomnias Heart Diseases Heart Failure Heart Failure With Normal Ejection Fraction Nervous System Diseases Obstructive Sleep Apnea Respiration Disorders Respiratory Tract Diseases Sleep Apnea Syndromes Sleep Apnea, Central Sleep Apnea, Obstructive Sleep Disordered Breathing Sleep Disorders, Intrinsic Sleep Wake Disorders

Age range

40 year and older

Sex eligibility

All sexes

Study type

Observational

Primary location

Royal Brompton Hospital

London, SW3 6NP, United Kingdom

About this study

Patients with sleep disordered breathing (SDB) and those with heart failure with preserved ejection fraction (HFpEF) share similar characteristics. Increasing age, hypertension, obesity, diabetes mellitus and atrial fibrillation are well recognised links in both groups. It also known that SDB is common in patients with heart failure, both with reduced and preserved ejection fraction. It is therefore hypothesised that among patients being referred for SDB assessment, we can identify a group with unrecognised HFpEF.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Aged ≥40 years and referred for respiratory polygraphy

Exclusion criteria

Previous diagnosis of Heart Failure
Treated sleep disordered breathing

Treatment and study plan

Primary outcomes

Number of Participants With Unrecognised Heart Failure With Preserved Ejection Fraction (HFpEF) in Cohort With Clinically Suspected Sleep Disordered Breathing (SDB)

Time frame: Baseline

The diagnosis of HFpEF was established using criteria set out in the European Society for Cardiology (ESC) guidelines based on clinical symptoms and/or signs, biomarker analysis (NT-proBNP) and evidence of structural cardiac remodeling or diastolic dysfunction on transthoracic echocardiography.

Sponsors and collaborators

Lead sponsor

Imperial College London

Other

Collaborators

Royal Brompton & Harefield NHS Foundation Trust

Registry information

Official study title

Heart Function in Patients Assessed for Sleep Disordered Breathing (SDB)

Important dates

Study start: 2017
Primary completion: 2019
Study completion: 2019
First posted: Jul 24, 2017
Registry last updated: Feb 17, 2021

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed