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NCT Number: NCT06183450

Hearing and Cognition in Aging Adults

This cohort study is expected to provide valuable insights into the complex interplay between auditory and cognitive functions and how they change over time. The results of this study will have important implications for the prevention, diagnosis, and treatment of age-related hearing and cognitive disorders

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Key information

Conditions

Presbycusis Cognition Disorders Cognitive Dysfunction Ear Diseases Hearing Disorders Hearing Loss Hearing Loss, Sensorineural Mental Disorders Nervous System Diseases Neurocognitive Disorders Neurologic Manifestations Otorhinolaryngologic Diseases Pathological Conditions, Signs and Symptoms Sensation Disorders Signs and Symptoms

Age range

45 year–50 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Ecole d'audioprothèse

Cahors, France

Location contact

Mariam ALZAHER, Dr

CONTACT

About this study

The aim of the study is to identify the early perceptual and cognitive alterations related to age-related hearing loss or presbycusis, establish a correlation between the degree of hearing loss and the deterioration of cognitive functions, and examine the effectiveness of hearing loss management in reversing observed cognitive impairments. This project has the potential to shed light on the importance of early detection of hearing impairments in preventing cognitive decline. The data collected from this cohort, rigorously assessed for both auditory and cognitive functions, could serve as the basis for several high-level scientific investigations.

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Normal hearing (Pure Tone Audiometry < or = 20 dB)
  • Residency in one of the three neighborhoods :
  • Affiliation with a social security system

Exclusion criteria

  • Individuals under guardianship, trusteeship or curators
  • History of neurological pathologies
  • Taking of psychotropic medication.

Treatment and study plan

auditory level

Diagnostic Test
  • Evaluation of auditory thresholds through audiometric tests.
  • Evaluation of speech comprehension in noise through a vocal audiometry test in noise (FraMatrix).
  • Evaluation of spatial auditory behavior and spatial precision using a spatial discrimination test (Minimum Audible Angle) and a static sound localization test in virtual reality.

cognitive level

Diagnostic Test
  • Evaluation of attention and short-term memory functions with verbal and non-verbal tasks: Digit Span Test and Reading Span Test.
  • Evaluation of inhibition capacities using the Stroop Test.
  • Evaluation of executive functions, visual attention, reasoning, and mental arithmetic using the Raven's Matrix test.

quality of life level

Diagnostic Test
  • Evaluation of quality of live level via Speech, Spatial and Qualities of Hearing Scale (SSQ-12) and EuroQol-5D questionnaires.

Primary outcomes

  1. Pure-ton audiometry

    Time frame: 5 years

    Pure-tone audiometry will be evaluated by collecting the threshold in air and bone conduction for both ears on each frequency tested (125-250-500-1000-2000-4000 and 8000 Hz), as well as the average hearing loss (MAP ) on all five frequencies.

Study contacts

Contact information is provided by the study sponsor or research team.

Mariam ALZAHER, Dr

CONTACT

[email protected]

Mathieu Marx, Pr

CONTACT

[email protected]

05 61 77 77 04 ext. +33

Sponsors and collaborators

Lead sponsor

University Hospital, Toulouse

Other

Registry information

Acronym: ACAV

Important dates

Study start
2024
Primary completion
2033
Study completion
2033
First posted
Dec 27, 2023
Registry last updated
Dec 27, 2023

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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