Healthy Lifestyle Intervention in Patients with Systemic Lupus Erythematosus: the Living Well with Lupus Study

assessed by measures of five standard variables (HDL cholesterol, triglycerides, fasting blood glucose, waist circumference and blood pressure - average of systolic and diastolic blood pressures). Z-score = [(50 - HDL cholesterol)/sd + (triglycerides - 150)/ sd] + [(fasting blood glucose - 100)/ sd] + [(waist circumference - 88)/ sd] + [(blood pressure - 115)/ sd]. Higher score values represent higher risk. *sd: standard deviation. Higher Z-score represent higher risk.

assessed by weight (kg) and height (m) that will be combined to report BMI in kg/m^2

assessed by measuring tape positioned at the midpoint between the last floating vertebra and the iliac crest.

assessed by blood sample analysis and combined to determine lipid profile

assessed by oral glucose tolerance test (OGTT)

assessed by auscultatory method with mercury sphygmomanometer

assessed by thigh-mounted accelerometer (ActivPAL™ micro)

assessed by three 24-hour food recall in non-consecutive days (being one of the days on the weekend)

assessed by tomography

assessed by flow-mediated vasodilatation (FMD)

The activity of the disease, which will be impaired by safety, will be assessed by the presence of anti-dsDNA, using the ELISA technique and confirmation by indirect immunofluorescence in Crithidia luciliae and assessed by the questionnaire Systemic lupus erythematosus disease activity index 2000 (SLEDAI-2000). Total score ranges from 0 to 105. Higher scores represent higher disease activity.

assessed by Systemic Lupus International Collaborating Clinics/ American College of Rheumatology - Damage Index. Total score range from 0 (no damage) to 46 (maximum damage).

assessed by the Visual Analogic Scale (0 and 10 scale). Higher values represent worst global health status.

assessed by focus group. A semi-structured script composed of open questions about intervention positive and negative points, barriers for physical activity practice and changes in food consumption, perceptions of health improvement or worsening (physical and psychological aspects), well-being, motivation to maintain the changes made, perspectives regarding health and disease.

maximum score is 100, with higher scores representing better life quality

score ranges from 40 to 280 with higher scores represent worst life quality.

evaluates the maximum number of stand-ups that a subject could perform from a standard height (i.e., 45 cm) armless chair within 30 s

evaluates the time required for the subject to rise from a standard arm chair, walk towards a line drawn on the floor three meters away, turn, return, and sit back down again

Patients will be instructed to squeeze the dynamometer as hard as possible

assessed by Fatigue Scale (FACIT). The final score can vary from 0 to 52, where higher final score representing higher level of fatigue.

assessed by sub-scale of Hospital Anxiety and Depression Scale (HADS), called HADS-A. Total score ranges from 0 to 21. Where higher final score representing higher level.

assessed by sub-scale of Hospital Anxiety and Depression Scale (HADS), called HADS-D. Total score ranges from 0 to 21. Where higher final score representing higher level.

Data from actigraph will come as these measures: Total Sleep Time (hours/day), Sleep Efficiency (%), Sleep Onset Latency (min), and Wake After Sleep Onset (min), and this data will be considered to determine the sleep quality.

assessed by analysis of blood sample

assessed by analysis of blood sample

assessed by serum cytokines

investigate the long-term effects of the intervention on maintenance of lifestyle behaviors and its effects on health