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NCT Number: NCT05784922

Health Opportunities and Promoters of Equitable Screening for Lung Cancer

The goal of this clinical trial is to promote lung cancer screening (LCS) uptake among Hispanic current and former smokers. The main questions it aims to answer are:

* What barriers do current and former Hispanic smokers face in the identification and documentation of their smoking status? * How can digital delivery of an educational video promote LCS uptake among current and former Hispanic smokers?

Participants will receive an educational video about lung cancer screening and complete brief, self-reported surveys afterwards.

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Key information

Conditions

Lung Cancer Behavior Diagnosis Disease Lung Diseases Lung Neoplasms Neoplasms Neoplasms by Site Pathologic Processes Pathological Conditions, Signs and Symptoms Respiratory Tract Diseases Respiratory Tract Neoplasms Smoking Smoking Behaviors Thoracic Neoplasms

Age range

50 year–80 year

Sex eligibility

All sexes

Study type

Observational

Primary location

Massachusetts General Hospital

Boston, Massachusetts, 02114, United States

Location status: Recruiting

Location contact

Efren Flores, MD

PRINCIPAL_INVESTIGATOR

Elyse Park, PhD

CONTACT

[email protected]

617-724-7792

About this study

Lung cancer remains the leading cause of cancer-specific mortality in the US, and Hispanics experience worse lung cancer outcomes and die at higher rates due to advanced stage at presentation. Lung cancer screening (LCS) can save many lives through early lung cancer detection among Hispanic current and former smokers.

Still, without increasing efforts to improve smoking status disclosure and documentation and tailored interventions to promote LCS uptake among Hispanic current and former smokers, this underserved population will continue to demonstrate disparities in lung cancer survival. Based on prior research experience, Dr. Flores has adapted the NIMHD research framework by incorporating elements from Ford's evidence-based theoretical model to guide the following proposed study aims:

  • To elucidate barriers and facilitators to consistent identification and documentation of smoking status to promote LCS uptake among Hispanic current and former smokers; 2) To assess feasibility, acceptability, and reach of the digital delivery of an educational video to promote LCS uptake among Hispanic current and former smokers; 3) To explore the effect of the digital delivery of the educational video to increase interest, intent, and scheduling of LCS uptake among Hispanic current and former smokers.

Impact: The successful completion of this research will serve as a foundation for developing novel interventions to overcome disparities and advance equity in lung cancer outcomes among Hispanics and other vulnerable populations.

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Must be 50-80 years old
  • Are a current or former smoker (quit within 15 years, or a cumulative smoking status of > 20 pack-years)
  • Not currently enrolled in Lung Cancer Screening
  • Must speak English or Spanish

Exclusion criteria

  • Has a clinical cognitive inability to provide informed consent for participation in the study or complete a brief survey
  • Currently diagnosed with lung cancer
  • Currently enrolled in lung cancer screening
  • Have participated in the focus groups discussions from Aim 1

Treatment and study plan

Educational Lung Cancer Screening (LCS) Video

Other

An educational video on lung cancer screening tailored to Hispanic current and former smokers.

Primary outcomes

  1. Participant outreach (contact) of digital link

    Time frame: Year 3

    Reach is defined as >20% of enrolled participants interacting with the digital delivery of the LCS educational video (i.e., partial or complete review of the LCS educational video).

Secondary outcomes

  1. Participant interaction with digital link

    Time frame: Year 3

    Overall proportion of participants that click on the embedded link to the successfully digitally delivered LCS educational videos

  2. Participant attention of LCS video

    Time frame: Year 3

    Duration of viewing the LCS video (i.e., partial or complete)

  3. Survey completion

    Time frame: Year 4

    Overall proportion of survey completion by participants.

Other outcomes

  1. Participant baseline smoking status

    Time frame: Year 5

    Identify salient participant characteristics obtained from the EHR (e.g., smoking status) among those that interacted with the digital delivery modality.

  2. Participant acceptability of intervention

    Time frame: Year 5

    Investigate attributes of the intervention to guide future research and development to create such an intervention (for future trials)

Study contacts

Contact information is provided by the study sponsor or research team.

Efren Flores, MD

CONTACT

[email protected]

617-724-4254

Sponsors and collaborators

Lead sponsor

Massachusetts General Hospital

Other

Collaborators

  • National Cancer Institute (NCI)

Registry information

Official study title

Health Opportunities and Promoters of Equitable Screening for Lung Cancer (HOPES for Lung Cancer)

Acronym: HOPES

Important dates

Study start
2023
Primary completion
2028
Study completion
2028
First posted
Mar 27, 2023
Registry last updated
Oct 14, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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