Health Benefits of Nutraceutical Supplementation in Older Adults.

Inclusion criteria

• Generally healthy participants with a life expectancy ≥ 5 years
• Male and female participants aged 50 to 80 years
• Body Mass Index (BMI) between 25 to 35 kg/m²
• Health not severely compromised (no life-threatening illness or disability)

Participants with:

• Intrinsic Capacity score showing mild to moderate decline
• Short Physical Performance Battery (SPPB) score between 9 to 11
• Montreal Cognitive Assessment (MoCA) score > 20 and ≤ 25
• Participants with or without comorbidities; if present, must be on a stable treatment regimen (same drug and dose) for at least 12 weeks prior to screening
• Able and willing to:
• Provide written informed consent
• Comply with study protocol requirements
• Read and write in English

Exclusion criteria

• Severe or uncontrolled chronic diseases (e.g., severe osteoarthritis, advanced cardiovascular disease, kidney failure, uncontrolled diabetes, severe COPD, terminal cancer)
• Physical disability requiring a walker or wheelchair
• Diagnosed dementia or cognitive impairment preventing protocol compliance
• Acute infection or illness within 3 months prior to enrollment
• Unstable medical conditions (e.g., recent myocardial infarction, unstable angina, uncontrolled hypertension)
• Major surgery within the past 6 months or planned during the study
• Severe psychiatric disorders unless well controlled
• Substance abuse within the past 6 months
• Participation in another clinical trial within the last 6 months
• Known allergy to any component of the nutraceutical kit
• Sedentary individuals unable or not advised to undergo resistance training as per protocol
• Clinically relevant macro- or micronutrient deficiency (as per investigator discretion)
• Pregnant or lactating women
• Women of childbearing potential not using adequate contraception or with a positive urine pregnancy test
• Current use of herbal products, nutraceuticals, Ayurvedic formulations, dietary supplements, or vitamin/mineral supplements and unwilling to discontinue during the study
• Any other condition or abnormal laboratory finding that, in the investigator's opinion, may interfere with study results or participant safety