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NCT Number: NCT07541742

Health and Nutritional Outcomes Among Young Females and Children in Southwest Bangladesh

This study aims to examine how societal and climate changes influence the nutritional status and fish consumption of young women over a 10 year period in southern Bangladesh, and how these factors affect their children's health. A cohort of 240 adolescents first studied in 2017 will be followed to assess changes in their dietary patterns, nutritional status, climate perceptions and mitigation practices, as well as the nutritional status of their children aged 6 months to 5 years.

The study in 2017 sampled 60 adolescent girls in each of four rural communities, plus a semi-rural community around a fish processing plant, representing in total 5 communities. Of these 60 X 5 = 300 girls, the current study follows up the individuals in the rural communities representing a cohort of 240.

Bangladesh faces high rates of adolescent malnutrition, with many girls married before 18 and suffering from chronic nutrient deficiencies. These issues have long-term impacts on health, productivity, and intergenerational well-being. By linking the fisheries and aquaculture sector, a key to Bangladesh's economy with public health and nutrition, this research aims to guide targeted policies for vulnerable coastal communities.

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Key information

Age range

5 month–27 year

Sex eligibility

All sexes

Study type

Observational

Primary location

International Centre for Diarrhoeal Disease Research, Bangladesh (icddr, b)

Dhaka, Capital Region, 1000, Bangladesh

Location contact

Gulshan Ara, MSc

CONTACT

[email protected]

+8802982700110

About this study

Aquatic foods are fundamental to the Bangladeshi diet, providing nearly two-thirds of total animal protein. Despite this, malnutrition remains a severe public health crisis with a complex etiology. Bangladesh faces a double burden of malnutrition, marked by persistently high rates of micronutrient deficiencies affecting roughly half of both pregnant and non-pregnant women alongside rising levels of overweight and obesity. These challenges are further exacerbated by substantial intrahousehold inequities in this patriarchal society. Disempowerment and early marriage disproportionately expose adolescent girls and young women to inadequate nutrient intake and poor health outcomes, perpetuating an intergenerational cycle of malnutrition. Furthermore, chronic undernutrition and stunting continue to affect a large proportion of children under five.

The problem is particularly acute in coastal communities, where climate change impacts such as salinity intrusion and extreme weather compromise food production and dietary diversity. Understanding and improving the dietary and nutritional status of adolescent girls and young women is therefore essential to breaking the cycle of poor health and ensuring long-term population well-being. Building on a 2017 study conducted with a cohort of 240 adolescents, this research aims to provide longitudinal insights into how nutritional status, female autonomy, aquatic food consumption, and dietary practices have influenced the health and well-being of these women and their children nearly after 10 years.

Hypotheses

  • Nutritional status, fish consumption, and female autonomy during adolescence (2017) influence the nutritional status of young women in 2026 and that of their offspring.
  • Fish consumption is positively associated with biological markers (omega-3 fatty acids, vitamin D levels, and stable isotope ratios in hair).

Objectives

  • To assess changes in nutritional status, fish intake, socioeconomic factors, and female autonomy among young women from 2017 to 2026, and examine their associations with the nutritional status of their children (6 months-5 years).
  • To investigate associations between assessed fish consumption and biological markers (omega-3, vitamin D, and stable isotope ratios in hair).

The study will be conducted in four distinct saline gradient agro-ecological zones across the shrimp-prawn farming regions of southwest Bangladesh, specifically in Fakirhat (Bagerhat District), Dumuria and Paikgacha (Khulna District), and Shyamnagor (Satkhira District).

Who can participate

Healthy volunteers accepted: Yes

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • Young women aged 22-27 years who previously participated in the 2017 study. See study description.
  • If the women has a child age between 6 months to 5 years, the child child is included to be assessed

Exclusion criteria

  • Participants with serious health conditions that may interfere with study procedures or data collection.

Treatment and study plan

The follow-up aims to evaluate natural changes occurring from adolescence to young adulthood with respect to the study objectives due to lifestyle and environmental factors, without any intervention.

Other

There is no intervention

Primary outcomes

  1. Omega-3 status

    Time frame: One sampling point between April and August 2026

    Eicosapentaenoic acid (EPA) in whole blood (% of total fatty acid)

  2. Omega-3 status

    Time frame: One sampling point between April and August 2026

    Docosahexaenoic acid (DHA) in whole blood (% of total fatty acid)

  3. Micronutrient status

    Time frame: One sampling point between April and August 2026

    Vitamin D (total 25-hydroxyvitamin D) concentration in blood, nmol/L

  4. Micronutrient status

    Time frame: One sampling point between April and August 2026

    Hemoglobin concentration in blood (g/dL)

  5. Micronutrient status

    Time frame: One sampling point between April and August 2026

    Ferritin concentration in blood (µg/L)

  6. Inflammation status

    Time frame: One sampling point between April and August 2026

    C-reactive protein concentration in blood (mg/L)

  7. Inflammation status

    Time frame: One sampling point between April and August 2026

    Alpha-1-acid glycoprotein concentration in blood (g/L)

Secondary outcomes

  1. Nutritional status

    Time frame: One measurement between April and August 2026

    Height (cm)

  2. Nutritional status

    Time frame: One measurement between April and August 2026

    Weight (kg)

  3. Nutritional status

    Time frame: One measurement between April and August 2026

    Mid-upper arm circumference (cm)

  4. Nutritional status

    Time frame: Between April and August 2026

    Body mass index (kg/m^2)

  5. Hair stable isotopes ratio

    Time frame: Between April 2026 to August 2026

    Isotope ratios of δ13C and δ15N in hair sample

  6. Fish consumption

    Time frame: Between April and August 2026

    7 days recall, questionnaire

Other outcomes

  1. Climate change perception and mitigation practice

    Time frame: Between April and August 2026

    Climate change and mitigation practice, questionnaire

  2. Women empowerment

    Time frame: Between April and August 2026

    Women empowerment will be obtained using women empowerment assessment tool, questionnaire.

  3. Dietary pattern, food frequency

    Time frame: Between April 2026 to August 2026

    Dietary pattern by food groups, questionnaire

  4. Child omega-3 status

    Time frame: One timepoint between April and August 2026

    If a woman has a child aged 6-59 months, the child is assessed for EPA concentration in blood (% of total fatty acids).

  5. Child omega-3 status

    Time frame: One measure between April and August 2026

    If the woman has a child aged 6 months to 5 years, the child is measured for DHA concentration in blood (% of total fatty acid)

  6. Micronutrient status, Child

    Time frame: April-August 2026

    If the woman has a child aged 6 months to 5 years, the child is measured for hemoglobin concentration in blood (g/L)

  7. Micronutrient status, Child

    Time frame: One sampling point between April and August 2026

    If the woman has a child aged 6 months to 5 years, ferritin concentration in blood (µg/L), will be measured.

  8. Micronutrient status, Child

    Time frame: One sampling point between April and August 2026

    If the woman has a child aged 6 months to 5 years, Vitamin D (total 25-hydroxyvitamin D) concentration in blood, nmol/L will be measured.

  9. Inflammation status, Child

    Time frame: One sampling point between April and August 2026

    If the woman has a child aged 6 months to 5 years, the child's C-reactive protein concentration in blood (mg/L) will be measured.

  10. Inflammation status, Child

    Time frame: One sampling point between April and August 2026

    If the woman has a child aged 6 months to 5 years, alpha-1-acid glycoprotein concentration in blood (g/L) will be measured.

  11. Nutritional status, Child

    Time frame: Between April and August 2026

    If the woman has a child aged 6-59 months, the child's length/height (cm) is measured.

  12. Nutritional status, Child

    Time frame: April-August 2026

    If the women has a child aged 6-59 months, the child is measured for weight (kg)

  13. Nutritional status, Child

    Time frame: April-August 2026

    If the woman has a child aged 6-59 months, the child is measured for MUAC (cm)

Study contacts

Contact information is provided by the study sponsor or research team.

Nanna Roos, PhD

CONTACT

[email protected]

+45 3532 0829

Sponsors and collaborators

Lead sponsor

University of Copenhagen

Other

Collaborators

  • Bangladesh Agricultural University (BAU)
  • International Centre for Diarrhoeal Disease Research, Bangladesh
  • Noakhali Science and Technology University
  • University of Aberdeen
  • University of Stirling

Registry information

Official study title

Health and Nutritional Outcomes Among Young Females and Children in Southwest Bangladesh: A Cohort Study

Acronym: AQUAFOOD

Important dates

Study start
2026
Primary completion
2026
Study completion
2026
First posted
Apr 21, 2026
Registry last updated
May 6, 2026

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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