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Completed

NCT Number: NCT07183631

Healing of Intrabony Defects Following Treatment With PRF or EMD

Objective: To evaluate clinically the long-term results following treatment of deep intrabony defects with either platelet-rich fibrin gel (PRF) or an enamel matrix derivative (EMD).

Methods: Twenty six patients diagnosed with advanced chronic periodontitis, and each of whom displaying one deep intrabony defect were randomly treated with open flap debridement and with either PRF (test) or EMD (Emdogain, Straumann, Basel, Switzerland) (control). The clinical outcomes were evaluated at baseline, at six months and three years after treatment. The primary outcome variable was the clinical attachment level (CAL).

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Key information

Conditions

Periodontal Bone Loss Alveolar Bone Loss Bone Diseases Bone Resorption Mouth Diseases Musculoskeletal Diseases Periodontal Atrophy Periodontal Disease Periodontal Diseases Platelet Rich Fibrin Stomatognathic Diseases

Age range

18 year and older

Sex eligibility

All sexes

Study type

Interventional

Phase

Phase 4

Primary location

Semmelweis University

Budapest, 1088, Hungary

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

  • No systemic conditions affecting treatment outcomes
  • Good oral hygiene [plaque index (PI) <1; Löe 1967]
  • Compliance with the maintenance program
  • Presence of at least one intra-bony defect with a probing depth (PD) of ≥6 mm and an intra-bony component of ≥3 mm confirmed by radiographs.

Exclusion criteria

  • significant medical conditions: irradiation in the maxillofacial area, uncontrolled diabetes or hypertension, systemic steroid or bisphosphonate treatment, pregnancy, or lactation, infectious diseases,
  • age <18 years, (3) smokers (>5 cigarettes/day),
  • high residual inflammation (FMBS >25%),
  • poor oral hygiene (FMPS >25%), and
  • defect-related factors: furcation involvement, endo-perio defects, horizontal defects, or multi-tooth defects .

Treatment and study plan

platelet rich fibrin

Other

Platelet-rich fibrin (PRF) was prepared according to the manufacturer's instructions. A blood sample was collected from the cubital vein in 10 ml tubes without anticoagulant and centrifuged at 3000 rpm for 10 minutes using a GLO GT416 table centrifuge (GLO Glotech Co. Ltd, Korea) and GLO PRP collection kit (GLO PRP-Kit, Glotech Co, Asan Choong-nam, Korea/ Glofinn, Finland).

Enamel matrix derivate

Other

In the control group, the root surface was conditioned with 24% ethylenediaminetetraacetic acid (EDTA) gel for two minutes, washed with physiological saline solution, dried, and treated with enamel matrix derivative (EMD), ("Emdogain", Straumann, Switzerland) per manufacturer recommendations.

Primary outcomes

  1. Probing pocket depth (PPD)

    Time frame: preop and after 6 months

Secondary outcomes

  1. Gingival recession

    Time frame: preop and after 6 months

  2. Clinical attachment loss

    Time frame: preop and after 6 months

Sponsors and collaborators

Lead sponsor

Semmelweis University

Other

Registry information

Official study title

Evaluating Treatment of Intra-bony Defects With PRF or EMD

Important dates

Study start
2021
Primary completion
2025
Study completion
2025
First posted
Sep 19, 2025
Registry last updated
Sep 19, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

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