Healing of Corneal Incision After Cataract Surgery in Diabetic Patients

The objective of this observational study was to understand the healing of corneal incision after cataract surgery in diabetic patients and its influencing factors. The main questions it aims to answer are:

Is corneal incision healing worse in diabetic patients after cataract surgery than in non-diabetic patients? What are the factors affecting corneal incision healing after cataract surgery in diabetic patients?

The results of anterior segment optical coherence tomography before and after cataract surgery in cataract patients with or without diabetes will be collected and analyzed.

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Key information

Conditions

Diabetes Cataract Diabetes Mellitus Endocrine System Diseases Eye Diseases Glucose Metabolism Disorders Lens Diseases Metabolic Diseases Nutritional and Metabolic Diseases

Sex eligibility

All sexes

Study type

Observational

Primary location

Zhongnan Hospital of Wuhan University

Wuhan, Hubei, 430071, China

Who can participate

Healthy volunteers accepted: No

Only the study team can determine whether someone qualifies for participation.

Inclusion criteria

Patients who experience blurred vision and painless visual acuity decline, and are diagnosed with cataract (with or without diabetes) through reliable intraocular pressure, visual acuity and slit lamp examinations, and for whom phacoemulsification of cataract can be considered.

Exclusion criteria

Use multiple eye drops before surgery.
Complicated by other eye diseases that affect corneal healing, such as keratitis, uveitis, glaucoma, etc.
Moderate to severe dry eye.
History of eye surgery.
Moderate to severe dry eye.
Grade 5 nuclear cataract.
Severe systemic diseases (such as chronic renal failure requiring dialysis, severe neurological diseases, immune diseases), pregnancy or lactation.

Treatment and study plan

Primary outcomes

volume of half cornea with surgical incision

Time frame: Before surgery; 1 week after surgery; 1 month after surgery
Defect of corneal incision healing

Time frame: 1 week after surgery; 1 month after surgery

Opening of internal orifice; Endothelial dislocation; Descemet's membrane detachment

Sponsors and collaborators

Lead sponsor

Zhongnan Hospital

Other

Registry information

Official study title

Corneal Incision Healing and Its Influencing Factors After Cataract Phacoemulsification in Diabetic Patients -- Based on Anterior Segment Optical Coherence Tomography

Important dates

Study start: 2024
Primary completion: 2024
Study completion: 2025
First posted: Jul 22, 2025
Registry last updated: Jul 22, 2025

OpenTrials presents study information sourced from ClinicalTrials.gov. The official registry record should be consulted for the latest information.

View the official ClinicalTrials.gov record (opens in a new tab)

This listing is for discovery and informational purposes only. It is not medical advice, does not guarantee that a study is recruiting, and does not determine eligibility. Contact the study team and a qualified healthcare professional when considering participation.

Published trials that share one or more normalized conditions with this study.

Completed